Platelet count and serum thrombopoietin level as predictors for morbidity and/or mortality in thrombocytopenic neonates

Figures & data

Table 1. Platelet count and thrombopoietin level in preterm and full-term thrombocytopenic neonates before and after recovery of bleeding (Wilcoxon matched pairs)

	Before	After	Z	P
Preterm neonates
Platelet count (10^3/μl)	150 (110–260)	260 (190–380)	4.19	<0.001
Thrombopoietin (pg/ml)	590 (320–860)	430 (240–620)	3.98	<0.001
Full-term neonates
Platelet count (10^3/μl)	110 (75–220)	200 (140–260)	3.92	<0.001
Thrombopoietin (pg/ml)	720 (530–910)	450 (390–520)	3.73	<0.001

NB: Values provided are medians (interquartiles: 25th and 75th).

Table 2. Basal platelet count and thrombopoietin level in preterm and full-term thrombocytopenic neonates in relation to survival (Mann–Whitney U-test)

	Died	Alive	Z	P
Preterm neonates
Platelet count (10^3/μl)	210 (170–295)	160 (110–192)	0.16	0.89
Thrombopoietin (pg/ml)	390 (285–410)	460 (315–510)	1.36	0.18
Full-term neonates
Platelet count (10^3/μl )	110 (105–160)	190 (180–310)	1.92	0.04
Thrombopoietin (pg/ml)	490 (410–525)	430 (420–495)	0.64	0.67

Table 3. Correlation between basal platelet count versus thrombopoietin and duration of recovery in relation to gestation (Spearmann rank correlation)

	All neonates		Preterm neonates		Full-term neonates
	r	P	r	P	r	P
Thrombopoietin	0.59	<0.001	0.69	<0.001	0.44	0.001
Duration of recovery	0.42	0.005	0.05	0.82	0.73	<0.001

Table 4. Prediction of duration of recovery in full-term thrombocytopenic neonates (linear regression)

	Unstandardized coefficients		Standardized coefficients beta	T	P
	B	Standard error
Platelet count (10^3/μl)	−0.076	0.016	−0.921	−4.861	<0.001
Mean platelet volume	−0.536	0.262	−0.388	−2.046	0.059
Thrombopoietin (pg/ml)	<0.001	<0.001	0.158	0.998	0.334
Gestational age (weeks)	−0.047	0.061	−0.122	−0.772	0.452
Constant	21.287	3.814		5.581	<0.001