Impact of serum adiponectin and leptin levels in acute leukemia

Figures & data

Table 1. Acute leukemia patient's characteristics

	ALL		AML
	n = 45		n = 35
Age (year)	42.8 ± 12.9 (19–60)		49.1 ± 12.9 (20.0–73.0)
Sex
Male	34 (75.5%)		21 (61.7%)
Female	11 (24.5%)		14 (38.3%)
Pallor	12 (26.6%)		15 (42.8%)
Bleeding tendency	15 (33.3%)		20 (57.1%)
Splenomegaly	20 (44.5%)		25 (71.4%)
Hepatomegaly	22 (48.8%)		27 (77.1%)
Lymphoadenopathy	16 (35.5 %)		12 (34.3%)
WBCs × 10^3 (cmm)	87.6 ± 25.8 (32.9–167.0)		80.4 ± 21.1 (37.8–193.0)
HB (g/dl)	8.6 ± 1.4 (6.5–11.5)		8.3 ± 2.0 (5.1–13.7)
Platelets (10^9/l)	90.08 ± 149.2 (5.3–675)		50.8 ± 32.2 (7.0–119.0)
BM blasts (%)	75.0 ± 19.2 (35.0–100.0)		65.1 ± 22.3 (10.0–90.0)
FAB classification (number)	L1	15	M1	3
	L2	22	M2	9
	L3	8	M4	12
			M5	7
			M6	4
Cytogenetic
Normal	17/45		10/35
Favorable
t(8;21)(q22;q22)	–		7/9
Inv16 t (16,16)	–		10/12
t(12,21)	9/45		–
Intermediate
t(9;11)(p22;q23)-MLLT3-MLL	–		5/35
Unfavorable
t(v;11)(v;q23)-MLL rearrangement	–		3/35
t(9,22)	10/45		–
t(8;14)(q24.1;q32)	9/45		–
Immunophenotyping
B lineage (CD 19, 20, 22)	37/45		–
T lineage (CD 2, 7,3)	8/45		–
Myeloid lineage (CD 13, 33, MPO)	–		35/35

Table 2. Adipocytokine levels (median, range) in different cytogenetically classified acute leukemia patients

Acute leukemia	Favorable (n = 53)	Intermediate (n = 5)	Unfavorable (n = 22)	P value
Leptin (ng/ml)	1.8 (0.5–2.2)	5.1 (2.5–6.4)	12.5 (5.4–22.5) 12.5	0.00
Adiponectin (ng/ml)	9.4 (7.2–10.5)	5.6 (3.8–7.5)	1.9 (0.7–3.6)	0.00

Figure 1. Serum leptin levels in acute leukemia patients versus controls.

Figure 2. Serum adiponectin levels in acute leukemia patients versus controls.

Table 3. Leptin and adiponectin levels in acute leukemia patients versus controls

acute leukemia	ALL (35/80)	AML (45/80)	Control (20)	P value
Leptin (ng/ml)	13.4 ± 4.9 (5.4–22.5) 12.5	2.7 ± 1.2 (0.5–5.1) 2.9	6.6 ± 3.2 (3.0–15.4) 5.5	0.00
Adiponectin (ng/ml)	12.7 ± 1.5 (9.8–15.5) 11.6	3.5 ± 1.6 (0.7–9.6) 3.9	18.8 ± 2.2 (12.9–22.0) 18.4	0.00

Table 4. Correlation between serum adiponectin levels and BM blast cells, WBCs, sLDH in acute leukemia patients

Adiponectin (ng/mL)	Blast cells (BM)	WBCs × 10^3/cmm (blood)	LDH (IU/L)
r P value	−0.599 <0.01	−0.448 >0.05	−0.762 <0.01

Table 5. Correlation between serum leptin levels and BM blast cells, blood leucocytic counts, and sLDH in ALL patients

Leptin (ng/mL)	Blast cells% (BM)	WBCs × 10^3/cmm (blood)	LDH (IU/l)
r	0.74	0.59	0.738
P value	0.01	0.02	0.01

Table 6. Correlation between serum leptin levels and BM blast cells, WBCs, LDH in AML patients

Leptin (ng/mL)	Blast cells (BM)	WBCs × 10^3/cmm (blood)	LDH (IU/l)
r	−0.542	0.250	−0.669
P value	<0.01	>0.05	<0.01