Abstract
Two collagen based nanocomposites were synthesised by initiating the reconstitution of collagen solutions in the absence or presence of alginate with simultaneous hydroxyapatite synthesis. The structural characteristics and thermal behaviours of both collagen-hydroxyapatite (M1) and collagen/alginate-hydroxyapatite (M2) were evaluated in comparison with rabbit bone (RB), which confirmed the bone-like features of synthetic nanocomposites. However, differences in microstructure, phase and composition were found among the respective samples calcined at 600 and 1000°C, as revealed by X-ray diffraction and scanning electron microscopy. Especially, in contrast to the presence of beta tricalcium phosphate in M1, pure HA was obtained in both M2 and RB after calcination at 1000°C, confirming that the introduction of alginate with Ca capturing capability is beneficial to achieve nanocomposites with better analogue to natural bone.
Acknowledgements
This work is supported by the National Basic Research Program of China (grant no. 2012CB933600) and the National Natural Science Foundation of China (grant no. 30670561).