CD4+ T cell subsets and Tax expression in HTLV-1 associated diseases

Abstract

Human T lymphotropic virus type 1 (HTLV-1) infection displays variable clinical manifestations. These include inflammatory diseases such as HTLV-1 associated myelopathy (HAM) or immunosuppressive conditions such as Strongyloides stercoralis hyperinfection. The viral protein, Tax causes activation and proliferation of T cells. We hypothesize that the expression of Tax in T cell subsets characterizes the clinical manifestations of HTLV-1. To test this hypothesis, we measured T helper 1 effector cells and regulatory T cells (Tregs) among Tax expressing lymphocytes from peripheral blood mononuclear cells (PBMCs) of 32 HTLV-1 infected patients with HAM, with S. stercoralis co-infection or with asymptomatic infection. We observed increased ratios of Th1/Treg among Tax expressing lymphocytes in HAM patients. These data suggest that the expression of Tax among the different target cells may explain the variable presentation of HTLV-1.

Keywords:

• HTLV-1
• Tax
• Immunology
• Regulatory T cells
• Th1
• Foxp3

We thank the UPCH/IMT HTLV-1 team for coordinating clinical procedures and providing the samples and Dr Angélica Terashima and the IMT parasitology laboratory for S. stercoralis microscopic analysis.