Figures & data
Figure 1. Liver stage life cycle of Plasmodium spp. A proportion of vivax sporozoites differentiate to a hypnozoite form that ultimately reactivates and proliferates leading to a blood-stage relapse.
Figure 2. Total dose of primaquine versus % cure.
Figure 3. The structures of leading 8-aminoquinolines: primaquine, tafenoquine.
Figure 4. Structures of NPC1161C and enantiomers B and C, and bulaquine.
Table 1. Key in vitro and in vivo data for primaquine, tafenoquine and NPC-1161B
Figure 5. Structures of quinolones, RC-12 and imidazolidinone – 8e.
Figure 6. Structures of KAI407 and optimised KDU691.
Figure 7. Phylogenetic tree of Plasmodium spp causing malaria in different species adapted from Hall.Citation72 Branches are not to scale but represent how closely related each species is with each other. The shorter the branch, the closer the genome of each Plasmodium spp. Each plasmodia species is associated with its natural vertebrate host and the number of assembled whole-genome sequences that are publically available, either in public databases or through genome centres is also labelled as described by Hall.
