Abstract
Background:
Increased risk of B-cell lymphoma in patients with autoimmune diseases is well known. Medical literature also links various autoimmune conditions with T-cell lymphomas (TCLs), a rarer but very heterogeneous group of generally aggressive neoplasms.
Methods:
Herein, we provide a comprehensive analysis of the available peer-reviewed literature on epidemiology, clinico-laboratory features and management of autoimmune diseases in patients with TCL. Most relevant publications were identified through searching the PubMed/Medline database for articles published from inception to June 2014.
Findings:
Prevalence of various hematologic and non-hematologic autoimmune conditions in patients with TCL appears to be increased. Due to the rarity of TCL, scientific literature on autoimmune conditions in these patients consists mainly of case series and isolated reports.
Conclusions:
Autoimmune disorders can develop prior to, during or after the onset of TCL. The diagnosis of TCL should prompt early recognition of certain autoimmune disorders if clinical suspicion exists. A dysfunctional immune response in these patients may be responsible for the occurrence of autoimmunity. Conversely, autoimmune conditions might create a favorable milieu for T-cell lymphoma pathogenesis. Therefore, their presence should increase the suspicion of TCL in an appropriate clinico-laboratory context. There is need for larger studies to assess further the TCL–autoimmunity relationship as prognosis and management of these patients can be considerably affected.
Transparency
Declaration of funding
This review was not funded.
Declaration of financial/other relationships
The senior author, Constantin A. Dasanu, is part of the Editorial Board of the Current Medical Research and Opinion journal. The remaining authors of this manuscript certify that they have no affiliations with or involvement in any organization or entity with any financial or non-financial interest, in the subject matter or materials discussed in this manuscript.
CMRO peer reviewers on this manuscript have no relevant financial or other relationships to disclose.