Figures & data
Table 1 Inclusion–exclusion criteria
Table 2 Protocol summary
Figure 1 Sequence of study procedures at a typical clinic visit.
Table 3 Representative list of prohibited medications* by category
Table 4 Demographic and baseline characteristics of enrolled subjects
Figure 2 Knee extension as measured by goniometry. Values are presented as Mean ± SEM. *p ≤ 0.05 indicates a statistically significant difference versus baseline or placebo. Number of completers: n = 24 in UC-II group (n = 3 dropouts); n = 20 in placebo group (n = 6 dropouts; n = 2 did not participate in ROM assessment).
Figure 3 Impact of stepmill procedure on the onset of pain. Values are presented as Mean ± SEM. *p ≤ 0.05 indicates a statistically significant difference from baseline. Number of completers: n = 19 in UC-II group (n = 3 dropouts; n = 5 did not have pain); n = 20 in placebo group (n = 6 dropouts; n = 1 did not have pain; n = 1 did not use stepmill).
Table 5 Subjects reporting complete loss of knee pain on stepmill test
Figure 4 Percent change in time to complete recovery from pain. Values are presented as Mean ± SEM. *p ≤ 0.05 indicates a statistically significant difference from baseline. Number of completers: n = 18 in UC-II group (n = 3 dropouts; n = 5 did not have pain; n = 1 time to complete recovery from pain was not achieved); n = 20 in placebo group (n = 6 dropouts; n = 1 did not have pain; n = 1 did not use stepmill).
Table 6 Summary of analysis of adverse events (AEs) in all subjects
