Initiating aerobic exercise with low glycogen content reduces markers of myogenesis but not mTORC1 signaling

Figures & data

Table 1 Participant characteristics

Fig. 1 Experimental design

Table 2 Muscle glycogen and substrate oxidation.

Adapted from Margolis et al. [12]

Fig. 2 Fold change before (PRE) and after (POST) steady-state for p-AMPK^Thr172 (A), p-AKT^Thr473 (B), p-mTOR^Ser2448 (C), p-p70S6K^Thr424/421 (D), and p-rpS6^Ser235/236 (E) relative to baseline (BL) values (dotted line) for low (LOW; circle) or adequate (AD; black square) glycogen status. Values are mean ± SD, n = 11. *Different than BL, P < 0.05. ^‡Different than PRE, P < 0.05. ⁺Different than AD, P < 0.05

Fig. 3 Fold change before (PRE) and after (POST) steady-state for PAX7 (A), MYOD (B), and MYOGENIN (C) relative to baseline (BL) values (dotted line) for low (LOW; circle) or adequate (AD; black square) glycogen status. Values are mean ± SD, n = 11. *Different than BL, P < 0.05. ^‡Different than PRE, P < 0.05. ⁺Different than AD, P < 0.05

MargolisLMWilsonMAWhitneyCC et al Exercising with low muscle glycogen content increases fat oxidation and decreases endogenous, but not exogenous carbohydrate oxidationMetabolism201997 1 8 1:CAS:528:DC%2BC1MXhtVajtbzJ https://doi.org/10.1016/j.metabol.2019.05.003

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Availability of data and materials

All extracted data are presented in this manuscript. The corresponding author may be contacted for any data requests or questions.