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Research

Adherence to metformin in adults with type 2 diabetes: a combined method approach

ORCID Icon, , , , , , , , , ORCID Icon, , ORCID Icon & ORCID Icon show all
Article: 61 | Received 28 Jun 2022, Accepted 02 Oct 2022, Published online: 04 Dec 2023

Figures & data

Fig. 1 Flowchart of patient recruitment

Fig. 1 Flowchart of patient recruitment

Table 1 Patient characteristics

Table 2 Metformin regimes taken by recruited patients

Fig. 2 Number of patients who sometimes, often, or always engaged in non-adherent behaviours to metformin stated in the MARS questionnaire

Fig. 2 Number of patients who sometimes, often, or always engaged in non-adherent behaviours to metformin stated in the MARS questionnaire

Fig. 3 Level of metformin exposure in recruited patients

Fig. 3 Level of metformin exposure in recruited patients

Fig. 4 Comparison of results of metformin adherence classification of adult patients with type 2 diabetes using the different methods of assessment. MARS: medication adherence report scale; DBS: dried blood spot

Fig. 4 Comparison of results of metformin adherence classification of adult patients with type 2 diabetes using the different methods of assessment. MARS: medication adherence report scale; DBS: dried blood spot

Table 3 HbA1c and random glucose levels as outcomes for non-adherence

Table 4 HbA1c and random glucose levels as outcomes for exposure

Table 5 Univariate analysis of possible factors affecting metformin adherence

Table 6 Factors independently linked to metformin adherence using logistic regression analysis

Supplemental material

Additional file 1: Fig. S1.

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Additional file 2: Fig. S2.

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Availability of data and materials

The data used to support the findings of this study are included in this published article.