Organophosphonic acids as drug candidates

Abstract

The discovery of phosphate mimetics that are suitable as drug candidates has been a challenging problem faced by medicinal chemists for many years. Several series of organophosphonic acids have been identified as phosphate mimetics and have resulted in multiple development candidates progressing to the clinic and even successfully reaching the market. This review intends to provide only a sampling of the recent patents covering dianionic phosphonic acids, demonstrating that phosphonates can be developed into suitable drug candidates.

Keywords::

• FBPase inhibitor
• phosphate mimetic
• phosphonate
• PTP1B inhibitor
• pyridoxal-5′-phosphate analogue
• RdRp inhibitor
• serine protease inhibitor

Acknowledgement

The author would like to thank SJ Hecker for editorial comments on this manuscript.