Abstract
Two related applications from AstraZeneca claim novel pyrazole derivatives and their process for preparation as trk kinase inhibitors for use in oncology. The compounds are claimed for stand-alone or combination therapy. The two series, which differ by position of attachment of the pyrazole group, are prepared from a common intermediate by reversing the order of the aminopyrazole step. TrkA kinase data are provided for three examples in each application.
Patent Details
Title Chemical compounds
Assignee AstraZeneca
Inventors Han Y, Lamb M, Mohr P, Yu D, Wang B, Wang T,
Priority date 16/02/2005 & 03/11/2005
Filing date 15/02/2006
Publication date 24/08/2006
Publication no. WO2006/087538
Title Chemical compounds
Assignee AstraZeneca
Inventors Lamb M, Mohr P, Wang B, Wang T, Yu D
Priority date 16/02/2005 & 01/12/2005
Filing date 15/02/2006
Publication date 24/08/2006
Publication no. WO2006/087530