Nanoparticles for controlled release of anti-biofilm agents WO2014130994 (A1): a patent evaluation

Abstract

Nanoparticles based on poly(dimethylaminoethyl methacrylate)-b-poly(dimethylaminoethyl methacrylate-co-propylacrylic acid-co-butyl methacrylate) (p-DMAEMA-b-(DMAEMA-co-PAA-co-BMA)) were loaded with farnesol or apigenin for the controlled, pH-dependent release of the two agents to inhibit pathogenic bacteria-producing biofilms. The inventions are mainly directed against Streptococcus mutans, the oral cavity bacterium responsible for dental caries.

Keywords:

• antibacterial agent
• biofilm
• nanoparticle
• pH-dependent controlled release
• poly(dimethylaminoethyl methacrylate
• Streptococcus mutans

Declaration of interest

The author has no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.