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Expert Opinion on Investigational Drugs Volume 18, 2009 - Issue 7
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Drug Evaluations

Cixutumumab

Kevin P McKian Mayo Clinic College of Medicine, Division of Medical Oncology, 200 First St. SW Rochester, 55905 MN, USA +1 507 266 0029; +1 507 284 1803; [email protected]
&
Paul Haluska Mayo Clinic College of Medicine, Division of Medical Oncology, 200 First St. SW Rochester, 55905 MN, USA +1 507 266 0029; +1 507 284 1803; [email protected]
, MD PhD
Pages 1025-1033 | Published online: 24 Jun 2009
 
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Abstract

The IGF pathway plays a major role in cancer cell proliferation, survival and resistance to antineoplastic therapies in many human malignancies. As such, interference with this pathway is the target of many investigational pharmacologic agents. Cixutumumab, a monoclonal antibody to IGF-1R, utilizes this concept. In this review, we summarize preclinical, pharmacologic and early clinical data regarding this agent and discuss the impact this drug might have on the future treatment of human cancers.

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