Figures & data
Box 1. Drug summary.
Figure 1. Positive and Negative Syndrome Scale (PANSS) total and factor scores are shown Citation[38,45,46] a,b. A. Total Score (30 items; score range, 30 – 210) is shown. Mean (SD) score at baseline: 87.2 (11.5) for PP and 86.8 (10.3) for placebo. B. Positive Symptom Factor Score (eight items; score range, 8 – 56) is shown. Mean (SD) score at baseline: 26.3 (5.0) for PP and 26.5 (5.5) for placebo. C. Negative Symptom Factor Score (seven items; score range, 7 – 49) is shown. Mean (SD) score at baseline: 20.9 (5.3) for total PP and 20.4 (5.1) for placebo. D. Disorganized Thoughts Factor Score (seven items; score range, 7 – 49) is shown. Mean (SD) score at baseline: 20.1 (4.7) for total PP and 19.8 (4.3) for placebo. E. Uncontrolled Hostility/Excitement Factor Score (four items; score range, 4 – 28) is shown. Mean (SD) score at baseline: 9.3 (3.2) for total PP and 9.3 (3.3) for placebo. F. Anxiety/Depression Factor Score (four items; score range, 4 – 28) is shown. Mean (SD) score at baseline: 10.6 (3.3) for total PP and 10.8 (3.3) for placebo.
![Figure 1. Positive and Negative Syndrome Scale (PANSS) total and factor scores are shown Citation[38,45,46] a,b. A. Total Score (30 items; score range, 30 – 210) is shown. Mean (SD) score at baseline: 87.2 (11.5) for PP and 86.8 (10.3) for placebo. B. Positive Symptom Factor Score (eight items; score range, 8 – 56) is shown. Mean (SD) score at baseline: 26.3 (5.0) for PP and 26.5 (5.5) for placebo. C. Negative Symptom Factor Score (seven items; score range, 7 – 49) is shown. Mean (SD) score at baseline: 20.9 (5.3) for total PP and 20.4 (5.1) for placebo. D. Disorganized Thoughts Factor Score (seven items; score range, 7 – 49) is shown. Mean (SD) score at baseline: 20.1 (4.7) for total PP and 19.8 (4.3) for placebo. E. Uncontrolled Hostility/Excitement Factor Score (four items; score range, 4 – 28) is shown. Mean (SD) score at baseline: 9.3 (3.2) for total PP and 9.3 (3.3) for placebo. F. Anxiety/Depression Factor Score (four items; score range, 4 – 28) is shown. Mean (SD) score at baseline: 10.6 (3.3) for total PP and 10.8 (3.3) for placebo.](/cms/asset/69f01a05-37a1-4513-828e-d5c170280a5d/ieop_a_909409_f0001_b.jpg)
Figure 2. Effect sizes at end point (13 weeks) for positive and negative syndrome scale total and factor scores for paliperidone palmitate versus placebo*.
Table 1. Significant treatment responses relative to placebo by symptom domain and paliperidone palmitate dosea,b.
Table 2. Least square mean change from baseline in positive and negative syndrome scale total and factor scores.