Nuclear factor kappa B and hepatitis viruses

Abstract

Background: Hepatitis can be caused by a number of viruses, which have similar clinical manifestations and render infected individuals at high risk of death from cirrhosis and liver cancer. Current therapies for hepatitis have limited effects and unsatisfactory patient outcomes. Nuclear factor kappa B (NF-κB) is critical for immune and inflammatory responses. During its lifetime the cell demands specific and highly regulated control of NF-κB activity. Objective: To develop novel strategies to overcome various hepatitides and related liver cancer with NF-κB as the key point. Methods: All aspects of NF-κB control with regard to hepatitis are covered. Results/conclusion: NF-κB plays an important role in the process of hepatitis and is hypothesized to be an anti-cancer factor in the subsequent inflammation-associated hepatocarcinogenesis.

Keywords::

• hepatitis virus
• inflammation-associated hepatocarcinogenesis
• inhibition
• interaction
• NF-κB
• regulation
• signaling pathway