Biomarkers for the diagnosis of deep vein thrombosis

Figures & data

Table 1. Summary of p value, sensitivity and specificity, PPV and NPV derived from a multivariable logistic regression model in which two combined biomarkers and/or a biomarker plus clinical score is the independent variable.

Variables	p-Value (regression)	Sensitivity (%)	Specificity (%)	NPV (%)	PPV (%)
sP-sel (≥ 90 ng/ml)	< 0.0001	28	96	72	72
sP-sel + Wells' score (≥ 90 ng/ml + ≥ 2)	< 0.0001	33	95	70	100
sP-sel + Wells' score (< 60 ng/ml + < 2)	< 0.0001	99	33	96	47
D-dimer (≤ 0.5 mg/l)	< 0.0001	98	29	80	40
D-dimer + Wells' score (≤ 0.5 mg/l + < 2)	< 0.0001	93	45	81	44
Wells' score (≥ 2)	< 0.0001	41	93	79	33
sP-sel + D-dimer (≥ 90 ng/ml + ≤ 0.5 mg/l)	< 0.0001	43	81	81	58

Adapted from [11] with permission of Sage Publications.

DVT: Deep venous thrombosis; NPV: Negative predictive value; PPV: Positive predictive value; sP-sel: Soluble P-selectin.

Ramacciotti E, Blackburn S, Hawley AE, Evaluation of soluble P-Selectin as a marker for the diagnosis of deep venous thrombosis. Clin Appl Thromb Hemost 2011;17(4):425-31

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