Figures & data
Table 1. TNM staging of colon and rectal cancer, American Joint Committee on Cancer Manual, 7th edition.
Table 2. Enrichment of circulating tumor cells by positive (using anti-EpCAM antibodies) and negative (non-EpCAM-based) selection.
Table 3. Enrichment of circulating tumor cells by utilization of other cell characteristics.
AJCC Cancer Staging Manual (7th Edition). Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A (Eds). Springer, NY, USA (2010). Talasaz AH, Powell AA, Huber DE et al. Isolating highly enriched populations of circulating epithelial cells and other rare cells from blood using a magnetic sweeper device. Proc. Natl Acad. Sci. USA 106(10), 3970–3975 (2009). Navin N, Kendall J, Troge J et al. Tumour evolution inferred by single-cell sequencing. Nature 472(7341), 90–94 (2011). Zieglschmid V, Hollmann C, Gutierrez B et al. Combination of immunomagnetic enrichment with multiplex RT-PCR analysis for the detection of disseminated tumor cells. Anticancer Res. 25(3A), 1803–1810 (2005). Nagrath S, Sequist LV, Maheswaran S et al. Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature 450(7173), 1235–1239 (2007). Stott SL, Hsu CH, Tsukrov DI et al. Isolation of circulating tumor cells using a microvortex-generating herringbone-chip. Proc. Natl Acad. Sci. USA 107(43), 18392–18397 (2010). Saliba AE, Saias L, Psychari E et al. Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays. Proc. Natl Acad. Sci. USA 107(33), 14524–14529 (2010). Dharmasiri U, Njoroge SK, Witek MA et al. High-throughput selection, enumeration, electrokinetic manipulation, and molecular profiling of low-abundance circulating tumor cells using a microfluidic system. Anal. Chem. 83(6), 2301–2309 (2011). Saucedo-Zeni N, Mewes S, Niestroj R et al. A novel method for the in vivo isolation of circulating tumor cells from peripheral blood of cancer patients using a functionalized and structured medical wire. Int. J. Oncol. (2012). Königsberg R, Gneist M, Jahn-Kuch D et al. Circulating tumor cells in metastatic colorectal cancer: efficacy and feasibility of different enrichment methods. Cancer Lett. 293(1), 117–123 (2010). Conant CG, Schwartz MA, Ionescu-Zanetti C. Well plate-coupled microfluidic devices designed for facile image-based cell adhesion and transmigration assays. J. Biomol. Screen. 15(1), 102–106 (2010). Naume B, Borgen E, Tøssvik S, Pavlak N, Oates D, Nesland JM. Detection of isolated tumor cells in peripheral blood and in BM: evaluation of a new enrichment method. Cytotherapy 6(3), 244–252 (2004). Tong X, Yang L, Lang JC, Zborowski M, Chalmers JJ. Application of immunomagnetic cell enrichment in combination with RT-PCR for the detection of rare circulating head and neck tumor cells in human peripheral blood. Cytometry B. Clin. Cytom. 72(5), 310–323 (2007). Desitter I, Guerrouahen BS, Benali-Furet N et al. A new device for rapid isolation by size and characterization of rare circulating tumor cells. Anticancer Res. 31(2), 427–441 (2011). Zhu P, Shelton DR, Li S et al. Detection of E. coli O157:H7 by immunomagnetic separation coupled with fluorescence immunoassay. Biosens. Bioelectron. 30(1), 337–341 (2011). Lin HK, Zheng S, Williams AJ et al. Portable filter-based microdevice for detection and characterization of circulating tumor cells. Clin. Cancer Res. 16(20), 5011–5018 (2010). Lu J, Fan T, Zhao Q et al. Isolation of circulating epithelial and tumor progenitor cells with an invasive phenotype from breast cancer patients. Int. J. Cancer 126(3), 669–683 (2010). Tan SJ, Lakshmi RL, Chen P, Lim WT, Yobas L, Lim CT. Versatile label free biochip for the detection of circulating tumor cells from peripheral blood in cancer patients. Biosens. Bioelectron. 26(4), 1701–1705 (2010). Hou HW, Warkiani ME, Khoo BL et al. Isolation and retrieval of circulating tumor cells using centrifugal forces. Sci. Rep. 3, 1259 (2013). Marrinucci D, Bethel K, Lazar D et al. Cytomorphology of circulating colorectal tumor cells:a small case series. J. Oncol. 2010, 861341 (2010).