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Expert Review of Proteomics Volume 5, 2008 - Issue 2
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Review

Biochemistry of Tau in Alzheimer’s disease and related neurological disorders

Nicolas Sergeant Inserm, U837, place de Verdun, 59045 Lille, France; Université Lille 2, Faculté de Médecine, Institut de Médecine prédictive et de Recherche thérapeutique, Centre de Recherches Jean-Pierre Aubert, place de Verdun, 59045 Lille, France
,
Alexis Bretteville Inserm, U837, place de Verdun, 59045 Lille, France; Université Lille 2, Faculté de Médecine, Institut de Médecine prédictive et de Recherche thérapeutique, Centre de Recherches Jean-Pierre Aubert, place de Verdun, 59045 Lille, France
,
Malika Hamdane Inserm, U837, place de Verdun, 59045 Lille, France; Université Lille 2, Faculté de Médecine, Institut de Médecine prédictive et de Recherche thérapeutique, Centre de Recherches Jean-Pierre Aubert, place de Verdun, 59045 Lille, France
,
Marie-Laure Caillet-Boudin Inserm, U837, place de Verdun, 59045 Lille, France; Université Lille 2, Faculté de Médecine, Institut de Médecine prédictive et de Recherche thérapeutique, Centre de Recherches Jean-Pierre Aubert, place de Verdun, 59045 Lille, France
,
Pierre Grognet Innogenetics NV, Industriepark Zwijnaarde 7, 9052 Gent, Belgium
,
Stephanie Bombois Université Lille 2, Faculté de Médecine, Institut de Médecine prédictive et de Recherche thérapeutique, Centre de Recherches Jean-Pierre Aubert, place de Verdun, 59045 Lille, France; Lille University Hospital, Department of Neurology, Memory Center, EA2691, Lille, France
,
David Blum Inserm, U837, place de Verdun, 59045 Lille, France; Université Lille 2, Faculté de Médecine, Institut de Médecine prédictive et de Recherche thérapeutique, Centre de Recherches Jean-Pierre Aubert, place de Verdun, 59045 Lille, France
,
André Delacourte Inserm, U837, place de Verdun, 59045 Lille, France; Université Lille 2, Faculté de Médecine, Institut de Médecine prédictive et de Recherche thérapeutique, Centre de Recherches Jean-Pierre Aubert, place de Verdun, 59045 Lille, France
,
Florence Pasquier Université Lille 2, Faculté de Médecine, Institut de Médecine prédictive et de Recherche thérapeutique, Centre de Recherches Jean-Pierre Aubert, place de Verdun, 59045 Lille, France; Lille University Hospital, Department of Neurology, Memory Center, EA2691, Lille, France
,
Eugeen Vanmechelen Innogenetics NV, Industriepark Zwijnaarde 7, 9052 Gent, Belgium
,
Susanna Schraen-Maschke Université Lille 2, Faculté de Médecine, Institut de Médecine prédictive et de Recherche thérapeutique, Centre de Recherches Jean-Pierre Aubert, place de Verdun, 59045 Lille, France; Inserm, U837, place de Verdun, 59045 Lille, France
&
Luc Buée Head of the team “Maladies Neurodégénératives et Mort Neuronale”, Inserm U837 – Jean-Pierre Aubert Research Centre, Université de Lille 2, Institut de Médecine Prédictive et Recherche Thérapeutique, Faculté de Médecine - Pôle Recherche, Place de Verdun, F-59045 Lille cedex France; Inserm, U837, place de Verdun, 59045 Lille, France. [email protected]
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Pages 207-224 | Published online: 09 Jan 2014
 
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Abstract

Microtubule-associated Tau proteins belong to a family of factors that polymerize tubulin dimers and stabilize microtubules. Tau is strongly expressed in neurons, localized in the axon and is essential for neuronal plasticity and network. From the very beginning of Tau discovery, proteomics methods have been essential to the knowledge of Tau biochemistry and biology. In this review, we have summarized the main contributions of several proteomic methods in the understanding of Tau, including expression, post-translational modifications and structure, in both physiological and pathophysiological aspects. Finally, recent advances in proteomics technology are essential to develop further therapeutic targets and early predictive and discriminative diagnostic assays for Alzheimer’s disease and related disorders.

Financial & competing interests disclosure

This work was supported by Inserm, CNRS, IMPRT, University of Lille 2, Lille County Hospital (CHR-Lille), Région Nord/Pas-de-Calais, FEDER, and grants from Association Française contre les Myopathies (AFM2006-1579 and AFM2007-1043), GIP ANR-05-BLANC-0320-01, GIS-Longévité, and Fédération pour la Recherche sur le Cerveau and from the European Community: APOPIS (contract LSHM-CT-2003-503330) and cNEUPRO (contract LSHM-CT-2007-037950).

Alexis Brettville is a recipient from a scholarship co-sponsored by both Région Nord/Pas-de-Calais and CHR-Lille. Eugeen Vanmechelen and Pierre Grognet are both employees from Innogenetics NV, Gent, Belgium.

The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

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