Proteomics for diabetes research: an update and future perspectives

Abstract

Diabetes is a common disease worldwide and can cause several complications, leading to systemic derangements and end-organ damage. Despite blood sugar control and adequate therapy with currently available drugs, diabetic complications remain a serious issue in clinical practice, indicating that our knowledge of diabetes and its complications is only at the tip of the iceberg. Better understanding of its pathogenesis and pathophysiology is crucial to achieve better therapeutic outcomes and to prevent its complications. This review provides an overview of proteomics and introduces proteomic technologies commonly used for diabetes research. Recent proteomic studies for the investigation of diabetes and its complications are summarized. Finally, the future perspectives for the field of proteomics in diabetes research are discussed.

Keywords::

• bioinformatics
• biomarkers
• diabetes
• diabetic nephropathy
• integrative omics
• pathogenesis
• pathophysiology
• proteome
• proteomics
• systems biology