Figures & data
T cells produce both Th2 cytokines, which promote eosinophilia, and IFN-g, which is involved in granuloma formation. Vascular damage may depend on T-cells, ANCA- or eosinophil-mediated cytotoxicity. ANCA: Antineutrophil cytoplasmic antibodies; DC: Dendritic cell; HMGB: High mobility group-1 protein; MPO: Myeloperoxidase; TEFF: T-cell terminally differentiated; TEM: T cell effector memory; TRAIL: Tumor necrosis factor-related apoptosis-inducing ligand.
![Figure 1. Antigen-driven clonal expansion of CD4+ and CD8+ T cells in Churg–Strauss syndrome.T cells produce both Th2 cytokines, which promote eosinophilia, and IFN-g, which is involved in granuloma formation. Vascular damage may depend on T-cells, ANCA- or eosinophil-mediated cytotoxicity. ANCA: Antineutrophil cytoplasmic antibodies; DC: Dendritic cell; HMGB: High mobility group-1 protein; MPO: Myeloperoxidase; TEFF: T-cell terminally differentiated; TEM: T cell effector memory; TRAIL: Tumor necrosis factor-related apoptosis-inducing ligand.](/cms/asset/17adab1b-4727-44ec-a25a-da44a416426d/ierm_a_11211853_f0001_b.jpg)