The current understanding of Stevens–Johnson syndrome and toxic epidermal necrolysis

Figures & data

Figure 1. Typical targets with three concentric zones in erythema multiforme majus.

Figure 2. Confluent purpuric macules and limited areas of skin detachment in Stevens–Johnson syndrome.

Figure 3. Detachment of large epidermal sheets in Stevens–Johnson syndrome/toxic epidermal necrolysis overlap; atypical target lesions are still present.

Figure 4. Hemorrhagic erosions of lips and oral cavity in erythema multiforme majus, Stevens–Johnson syndrome and toxic epidermal necrolysis.

Figure 5. Severe eye involvement in erythema multiforme majus, Stevens–Johnson syndrome and toxic epidermal necrolysis.

Table 1. Severity of illness score for toxic epidermal necrosis.

Factor	Score	Weight/score value^†
Age	≥40 years	1
Malignancy	Yes	1
Body surface area detached (day 1)	≥10%	1
Tachycardia	≥120/min	1
Serum urea	≥10 mmol/l	1
Serum glucose	≥14 mmol/l	1
Serum bicarbonate	<20 mmol/l	1
	Possible score	0–7

^†The higher the total score value, the poorer the prognosis of the patient.

Adapted with permission from [36].

Activity Evaluation: Where 1 is strongly disagree and 5 is strongly agree

	1	2	3	4	5
1. The activity supported the learning objectives.
2. The material was organized clearly for learning to occur.
3. The content learned from this activity will impact my practice.
4. The activity was presented objectively and free of commercial bias.

Bastuji-Garin S, Fouchard N, Bertocchi M, Roujeau JC, Revuz J, Wolkenstein P. SCORTEN: a severity-of-illness score for toxic epidermal necrolysis. J. Invest. Dermatol.115, 149–153 (2000).

 PubMed Web of Science ®Google Scholar