miRNAs and diabetes mellitus

Figures & data

Figure 1. miRNAs that are dysregulated with the progression of diabetic complications: diabetic nephropathy, diabetic cardiovascular diseases, diabetic retinopathy and endothelial dysfunction.

Figure 2. miRNAs that are implicated in lipid metabolism.

ABC: ATP-binding cassette transporter; CETP: Cholesterylester transfer protein; FDFT1: Farnesyl-diphosphate farnesyltransferase 1; FXR: Farnesoid X receptor; HDL: High-density lipoprotein; HMGCR: HMC-CoA receptor; IDL: Intermediate-density lipoprotein; LCAT: Lecithin:cholesterol acyltransferase; LDL: Low-density lipoprotein; LDLR: Low-density lipoprotein receptor; LRP: Low-density lipoprotein receptor-related protein; LXR: Liver X receptor; MTP: Microsomal triaglyceride transfer protein; NPC1L1, Niemann-Pick disease, type C1, gene-like 1; PANK: Pantothenate kinase; PPAR: Peroxisome proliferator-activated receptor; PXR: Pregnane X receptor; RXR: Retinoid X receptor; SCARB1: Scavenger receptor class B, member 1; SOAT1: Sterol O-acyltransferase 1; SQLE: Squalene epoxidase; VLDL: Very-low-density lipoprotein.

Table 1. Implications of miRNAs in diabetes-associated hepatic pathophysiology and glucose metabolism.

miRNAs	Study model	Ref.	miRNAs	Study model	Ref.	miRNAs	Study model	Ref.
miR-15b	T2D rat model	[4]	miR-195	T2D rat model	[4,58]	miR-30e	T2D rat model	[50]
miR-17-3p	Obese mice	[112]	miR-2	Obese mice	[6]	miR-31	Obese mice	[6]
miR-19a	T2D mouse model	[113]	miR-22	T2D rat model	[50]	miR-33	T2D mouse model	[113]
miR-100	T2D rat model	[4]	miR-23a	T2D rat model	[50]	miR-34a	Obese mice T1D mouse model MIN6B1	[6,7,112]
miR-103	Obese mice T2D rat model	[4,58,114]	miR-26b	T2D rat model	[50]	miR-34c	T2D mouse model	[113]
miR-107	Obese mice	[6]	miR-27b	T2D rat model	[4]	miR-326	Obese mice T2D mouse model	[112,113]
miR-122	T1D mouse model	[6]	miR-29a	T2D rat model	[58]	miR-328	T2D mouse model	[113]
miR-124a	MIN6 cell line MIN6B1 cell line	[46,115]	miR-29b	T2D rat model	[58]	miR-329	Obese mice	[112]
miR-125a	T2D rat model	[50,58]	miR-29c	Obese mice T2D rat model	[6,50,58]	miR-330	Obese mice	[112]
miR-125b	T2D rat model	[4]	miR-200a	Obese mice T2D rat model	[4,6]	miR-335	T2D mouse model T2D rat model	[4,113]
miR-126	T2D rat model	[4]	miR-201	Obese mice	[112]	miR-335-5p	Obese mice	[6]
miR-129-3p	T2D mouse model	[113]	miR-205	Obese mice	[112]	miR-365	T2D rat model	[50]
miR-133a	Obese mice T2D mouse model	[112,113]	miR-207	T2D mouse model	[113]	miR-375	MIN6 cell line INS-1E cell line miR-375-knockout mouse model	[2,114]
miR-137	T2D mouse model	[113]	miR-210	T2D rat model	[50]	miR-380-5p	Obese mice	[112]
miR-140*	T2D rat model	[4]	miR-212	T2D mouse model	[113]	miR-384	T2D mouse model	[113]
miR-142-5p	T2D mouse model	[113]	miR-221	Obese mice GK rats	[6,50]	miR-409	T2D mouse model	[113]
miR-144	T2D mouse model	[8,113]	miR-222	GK rats T2D rat model	[4,50]	miR-422b	T2D rat model	[4]
miR-146	T2D mouse model T2D rat model	[4,113]	miR-223	GK rats	[50]	miR-434-3p	T2D mouse model	[113]
miR-151	Obese mice	[112]	miR-290	T2D rat model	[4]	miR-448	T2D mouse model	[113]
miR-183	T2D mouse model	[115]	miR-292	T2D rat model	[4]	miR-451	Obese mice	[6]
miR-191	T2D rat model	[4]	miR-296	T2D rat model	[4]	miR-467	T2D mouse model	[113]
miR-193	T2D rat model	[4]	miR-298	Obese mice	[112]	miR-9	INS-1E cell line	[44]
miR-194	Obese mice	[6]	miR-30a*	T2D rat model	[50]	miR-96	MIN6B1 cell line	[115]

T2D: Type 2 diabetes.

Table 2. miRNAs associated with adipogenesis, adipocyte differentiation and obesity.

miRNAs	Study model	Ref.	miRNAs	Study model	Ref.	miNAs	Study model	Ref.
let-7	3T3-L1	[116,117]	miR-151	Obese mice	[112]	miR-30a*	Human adipocytes	[88]
miR-10b	3T3-L1	[118]	miR-152	3T3-L1	[118]	miR-30a-5p	3T3-L1 Obese adipose tissue	[52]
miR-15a	3T3-L1	[119]	miR-181	3T3-L1	[117,118]	miR-30c	3T3-L1 Obese adipose tissue	[52]
miR-17-3p	Obese mice	[112]	miR-182	3T3-L1	[118]	miR-33	In vitro, in vivo	[101]
miR-17-5p	Human adipose tissue	[90]	miR-183	3T3-L1	[118]	miR-34a	Obese mice	[112]
miR-17/92	3T3-L1	[120]	miR-185	3T3-L1	[118]	miR-34c	3T3-L1	[118]
miR-101	3T3-L1	[118]	miR-197	Human adipose tissue	[90]	miR-322	3T3-L1	[117]
miR-101b	3T3-L1	[118]	miR-27a/b	3T3-L1	[117]	miR-326	ADSC	[127]
miR-103	3T3-L1 Obese adipose tissue	[52,117,118]	miR-29a/b/c	T2D rat model	[58]	miR-328	Obese mice	[112]
miR-107	3T3-L1 Obese adipose tissue	[52,117]	miR-200	MSC	[124]	miR-329	Obese mice	[112]
miR-122	Obese mice	[92]	miR-205	Obese mice	[112]	miR-330	Obese mice	[112]
miR-125a/b	3T3-L1 T2D rat model	[50,52]	miR-206	Brown adipocytes	[122]	miR-335	T2D rat model	[4,113]
miR-132	hAD-MSCs Human adipose tissue	[90,121]	miR-207	T2D rat model	[4]	miR-347	T2D rat model	[4]
miR-133a	Obese mice Brown adipocytes	[112,122]	miR-210	3T3-L1	[117]	miR-355	3T3-L1	[117]
miR-134	Human adipose tissue	[90]	miR-221	3T3-L1 Obese adipose tissue	[52]	miR-370	HepG2 cells	[94]
miR-138	hAD-MSCs	[123]	miR-222	3T3-L1 Obese adipose tissue	[52]	miR-378/miR-378*	3T3-L1	[95]
miR-140*	T2D rat model	[4]	miR-224	3T3-L1	[118]	miR-380-5p	Obese mice	[112]
miR-143	3T3-L1 Obese adipose tissue	[52]	miR-21	T2D rat model MSC	[4,125]	miR-422b	3T3-L1 Obese adipose tissue	[52]
miR-144	T2D mouse model	[8]	miR-24	C3H10T1/2 cell line	[126]	miR-448	3T3-L1	[128]
miR-145	Human adipose tissue	[90]	miR-26a	3T3-L1	[118]	miR-487b	T2D rat model	[4]
miR-148a	3T3-L1 Obese adipose tissue	[52,117]	miR-298	Obese mice	[112]	miR-519d	Obese adipose tissue	[57]
miR-150	3T3-L1	[95]	miR-31	C3H10T1/2 cell line ADSC	[126,127]	miR-99a	3T3-L1 Human adipose tissue	[90,118]

ADSC: Adipose-derived stem cell; hAD-MSC: Human adipose-derived mesenchymal stem cell; MSC: Mesenchymal stem cell; T2D: Type 2 diabetes.

Table 3. Diabetes-related miRNAs in the skeletal muscle.

miRNAs	Study model	Ref.	miRNAs	Study model	Ref.	miRNAs	Study model	Ref.
Let-7f	T2D rat model	[45]	miR-148a	T2D rat model	[58]	miR-34*	T2D rat model	[58]
miR-15a/b	Insulin-resistant human muscle	[61]	miR-150	T2D rat model	[58]	miR-301	T2D rat model	[45]
miR-19b	T2D rat model	[58]	miR-152	T2D rat model Insulin-resistant human muscle	[58,61]	miR-335	T2D rat model	[58]
miR-100a	Insulin-resistant human muscle	[61]	miR-185	Insulin-resistant human muscle	[61]	miR-379	T2D rat model	[58]
miR-106b	Insulin-resistant human muscle	[61]	miR-19b	T2D rat model	[58]	miR-424	T2D rat model	[45]
miR-126	T2D rat model	[45]	miR-190	Insulin-resistant human muscle	[61]	miR-434*	T2D rat model	[58]
miR-130a	T2D rat model	[45,58]	miR-199a	T2D rat model	[58]	miR-450	T2D rat model	[45]
miR-133a	Insulin-resistant human muscle	[61]	miR-23a/b	T2D rat model	[45]	miR-451	T2D rat model	[58]
miR-143	Insulin-resistant human muscle	[61]	miR-29a/b/c	T2D rat model	[58]	miR-98	Insulin-resistant human muscle	[61]
miR-144	T2D mouse model	[8]	miR-299*	T2D rat model	[58]	miR-99a	Insulin-resistant human muscle	[61]

T2D: Type 2 diabetes.

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