Updates on uterine papillary serous carcinoma

Figures & data

Figure 1. Proposed uterine papillary serous carcinoma management algorithm.

BSO: Bilateral salpingo-oophorectomy; CT: Computed tomography; PA: Pelvic angle; TH: Total hysterectomy; UPSC: Uterine papillary serous carcinoma.

Reproduced with permission from [79].

Table 1. Contrasting features of endometrioid adenocarcinoma versus uterine papillary serous carcinoma.

Feature	EEC	UPSC
Demographic risk factors	Younger age Unopposed estrogen • Obesity (endogenous) • Unopposed oral estrogen (exogenous)	Older age Thin Race?
Clinicopathologic risk factors predictive or metastatic disease or recurrence	Myometrial invasion Lymphovascular space involvement Tumor size Tumor grade Lymph node involvement	None; all can recur in the absence of ‘risk factors’
Histologic grade	Low Intermediate High	High
Stage at presentation (incidence [%])	I (73%) II (11%) III (13%) IV (3%)	I (54%) II (8) III (22%) IV (16%)
Patterns of recurrence	Locoregional	Extrapelvic
Molecular alterations: PTEN ER/PR p53 HER-2/neu overexpressed Claudin 3/4 overexpressed Bcl-2	80% mutated Positive Mutations rare 10–30% NA NA	Mutations rare Negative 90% mutated 45% Yes Yes

EEC: Endometrioid endometrial carcinoma; ER: Estrogen receptor; MSI: Microsatellite instability; NA: Not applicable; PR: Progesterone receptor; UPSC: Uterine papillary serous carcinoma.

Data from [10–39].

Activity evaluation

Where 1 is strongly disagree and 5 is strongly agree
	1	2	3	4	5
The activity supported the learning objectives.
The material was organized clearly for learning to occur.
The content learned from this activity will impact my practice.
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Boruta DM 2nd, Gehrig PA, Fader AN, Olawaiye AB. Management of women with UPSC: a Society of Gynecologic Oncology (SGO) review. Gynecol. Oncol.115(1), 142–153 (2009).

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