Abstract
Evaluation of: Wiser A, Gonen O, Ghetler Y, Shavit T, Berkovitz A, Shulman A. Addition of dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: a randomized prospective study. Hum. Reprod. 25(10), 2496–2500 (2010).
Management of poor-responder patients still remains among the foremost challenging issues in reproductive medicine. Albeit with limited success, various strategies have been practiced to overcome this problem. In some preliminary reports, the use of dehydroepiandrosterone prior to controlled ovarian stimulation regimens, which is proposed to act as a steroid prehormone for ovarian follicular sex steroidogenesis, has been suggested as an alternative strategy for the treatment of poor-responder patients. Recently, a randomized controlled trial has also supported these preliminary results.
Financial & competing interests disclosure
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
No writing assistance was utilized in the production of this manuscript.