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Abstract
Evaluation of: Bronkhorst IH, Ly LV, Jordanova ES et al. Detection of M2-macrophages in uveal melanoma and relation with survival. Invest. Ophthalmol. Vis. Sci. 52(2), 643–650 (2011).
Tumor-associated macrophages have been related to a worse prognosis for survival in several tumors, among them uveal melanoma. In particular for proangiogenic and anti-inflammatory M2-type macrophages, a contributory role to tumor growth has been described. This study demonstrated that most tumor-associated macrophages in uveal melanoma exhibited the M2-phenotype. Tumors with monosomy 3 that have an unfavorable prognosis exhibited significantly more M2-type macrophages than tumors with disomy of chromosome 3. These findings point to a possible pathophysiologic mechanism that links an inflammatory phenotype in uveal melanoma with structural chromosomal abnormalities such as monosomy 3.
Financial & competing interests disclosure
Hans Grossniklauas and Martina Herwig were supported in part by an unrestricted departmental grant from Research to Prevent Blindness, Inc., NIH grant P30EY06360 and the German Research Foundation (DFG). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.