Molecular profiling of laryngeal cancer

Abstract

Head and neck squamous cell carcinoma, including laryngeal cancer, is considered to progress from dysplasia to invasive cancer through well-defined clinical and histological stages. Numerous genetic alterations have been described in laryngeal squamous cell carcinoma, but the molecular mechanisms contributing to initiation and progression of laryngeal cancer are still poorly understood. Genomic, transcriptomic and protein alterations in laryngeal cancer progression are key areas for the current research aimed at finding instruments for classification, prognostication and patient-tailored treatment. We present a review of the current literature and discuss the use of array-based technologies in revealing the molecular portrait of laryngeal cancer.

Keywords::

• carcinogenesis
• cDNA microarray
• comparative genomic hybridization
• genetic
• head and neck
• laryngeal cancer
• oligonucleotide microarray
• protein
• proteomics
• squamous cell carcinoma
• tissue microarray

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.