Figures & data
(A) In this figure, the relationship between vital oncogenic transcriptome networks and the miRNAome are graphically represented. Target mRNAs for each major pathway are represented by circles with a unique color. miRNAs are represented as hairpin structures in the centre. The arrows connecting miRNAs and mRNAs indicate validated mRNA–miRNA interactions. The small arrow in the circles indicates the biological effects on the pathway by the miRNA acting on its target. (B) Gene–protein network in normal tissues and in cancer. miRNAs are transcribed from miRNA noncoding genes, which have their own transcriptional unit, or from introns of protein-coding genes. In general, one gene is transcribed to one mRNA and translated to one protein. By contrast, miRNAs are transcribed from one, or in certain cases, two genes. miRNAs coordinately regulate multiple mRNAs (shown as a net of connections), thus affecting the output of many proteins. miRNAs have a crucial role in keeping the gene–protein network interconnected.
CDC42: Cell division cycle 42; CEBPB: CCAAT/enhancer binding protein β; DNMT: DNA methyltransferase; HDAC4: Histone deacetylase 4; HOXA1: Homeobox A1; HOXD10: Homeobox D10; KIT: v-kit Hardy–Zuckerman 4 feline sarcoma viral oncogene homologue; MCL1: Myeloid cell leukemia sequence 1 (BCL-2-related); MLH1: MutL homologue 1, colon cancer, nonpolyposis type 2; MMP2: Matrix metalloproteinase 2; MSH: MutS homologue, colon cancer, nonpolyposis type 1; PDCD4: Programmed cell death 4; PTEN: Phosphatase and tensin homologue; SHIP1: Src homology 2 domain-containing inositol 5-phosphatase 1; SOX4: SRY (sex-determining region Y)-box 4; SP1: Sp1 transcription factor.
Reproduced with permission from Citation[6].
![Figure 1. Transcriptome–miRNA networks in cancer.(A) In this figure, the relationship between vital oncogenic transcriptome networks and the miRNAome are graphically represented. Target mRNAs for each major pathway are represented by circles with a unique color. miRNAs are represented as hairpin structures in the centre. The arrows connecting miRNAs and mRNAs indicate validated mRNA–miRNA interactions. The small arrow in the circles indicates the biological effects on the pathway by the miRNA acting on its target. (B) Gene–protein network in normal tissues and in cancer. miRNAs are transcribed from miRNA noncoding genes, which have their own transcriptional unit, or from introns of protein-coding genes. In general, one gene is transcribed to one mRNA and translated to one protein. By contrast, miRNAs are transcribed from one, or in certain cases, two genes. miRNAs coordinately regulate multiple mRNAs (shown as a net of connections), thus affecting the output of many proteins. miRNAs have a crucial role in keeping the gene–protein network interconnected.CDC42: Cell division cycle 42; CEBPB: CCAAT/enhancer binding protein β; DNMT: DNA methyltransferase; HDAC4: Histone deacetylase 4; HOXA1: Homeobox A1; HOXD10: Homeobox D10; KIT: v-kit Hardy–Zuckerman 4 feline sarcoma viral oncogene homologue; MCL1: Myeloid cell leukemia sequence 1 (BCL-2-related); MLH1: MutL homologue 1, colon cancer, nonpolyposis type 2; MMP2: Matrix metalloproteinase 2; MSH: MutS homologue, colon cancer, nonpolyposis type 1; PDCD4: Programmed cell death 4; PTEN: Phosphatase and tensin homologue; SHIP1: Src homology 2 domain-containing inositol 5-phosphatase 1; SOX4: SRY (sex-determining region Y)-box 4; SP1: Sp1 transcription factor.Reproduced with permission from Citation[6].](/cms/asset/fae3690a-2bd6-46f8-8b55-9db97559e5ef/ierd_a_11207245_f0001_b.jpg)
