The Role and Underlying Mechanism of miR-1299 in Cancer

Figures & data

Figure 1. Biogenesis and function of miRNA.

Table 1. The expression, targets, biological functions and role of miR-1299 in cancer.

Cancer type	Expression	Site	Target	Biological function	Role	Ref.
ESCC	Down	Tissue	EGFR-Akt-mTOR	Promote autophagy	Tumor suppressor	[21]
Breast cancer	Down	Tissue and cell	CDK6	Repress breast cancer proliferation, migration and invasion	Tumor suppressor	[22]
Cholangiocarcinoma	Down	Tissue and cell	–	Repress cell growth and metastasis	Tumor suppressor	[23]
Prostate cancer	Down	Tissue and cell	NEK2	Inhibit proliferation, invasion and migration of Pla cells	Tumor suppressor	[24]
Gastric cancer	Down	Tissue and cell	ETS1	Decrease the viability of GC cells, increase the rate of apoptosis	Tumor suppressor	[25]
TNBC	Down	Tissue and cell	MMP	Inhibit cell migration and invasion of TNBC	Tumor suppressor	[26]
Melanoma	Down	Tissue and cell	ARG2 tyrosinase	Promote autophagy	Tumor suppressor	[27]
Colon cancer	Down	Tissue and cell	STAT3	Inhibit colon cancer cell growth	Tumor suppressor	[28]
HCC	Down	Tissue and cell	CDK6	Inhibit cell proliferation	Tumor suppressor	[29]
Ovarian cancer	Down	Tissue and cell	NOTCH3	Induce cardiomyocytes apoptosis	Tumor suppressor	[30]
Cervical cancer	Up	PI003-induced apoptosis of cells	P1M1	Promote cell apoptosis	Tumor suppressor	[31]

ESCC: Esophageal squamous cell carcinoma; HCC: Hepatocellular carcinoma; TNBC: Triple-negative breast cancer.

Figure 2. miR-1299 promotes autophagy and apoptosis of tumor cells by targeting EGFR-Akt-mTOR, Bcl-2, PIM1 and ARG2-tyrosinase.

Figure 3. miR-1299 inhibits tumor cell proliferation, migration and invasion by targeting CDK6, NEK2, MMP and STAT3.

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