Prediction Scale of Response to Liraglutide Therapy As the Method for Increase of Treatment Efficacy in Type 2 Diabetes

Figures & data

Table 1. Characteristics of all participants included in the study and dynamics of the studied parameters during therapy with liraglutide.

	Prior therapy	n	p-value	In 6 months of therapy	n	p-value
Age, years (no T2D) Age, years (T2D)	43.71 ± 13.67 53.33 ± 8.64	14 27	0.022	-	14 27
Gender, % of women (no T2D) Gender, % of women (T2D)	57.1 66.7	14 27	0.548	-	14 27
Body weight, kg (no T2D) Body weight, kg (T2D)	118.48 ± 32.42 116.50 ± 29.71	14 27	0.912	107.25 ± 29.91 111.22 ± 29.50	14 27	0.573
BMI, kg/m^2 (no T2D) BMI, kg/m^2 (T2D)	38.72 ± 7.37 40.66 ± 7.75	14 27	0.438	35.12 ± 8.18 38.94 ± 7.71	14 27	0.059
Fasting glycemia, mmol/l (no T2D) Fasting glycemia, mmol/l (T2D)	5.60 ± 1.19 8.68 ± 2.31	14 13	<0.001	5.19 ± 0.66 6.77 ± 1.36	14 11	<0.001
Glycated hemoglobin, % (no T2D) Glycated hemoglobin, % (T2D)	5.57 ± 0.50 8.08 ± 1.27	14 26	<0.001	5.38 ± 0.58 7.36 ± 1.13	14 24	<0.001
Insulin concentration in blood, pmol/l (no T2D) Insulin concentration in blood, pmol/l (T2D)	223.59 ± 102.53 194.83 ± 146.90	11 8	0.456	120.36 ± 66.09 117.77 ± 73.47	10 6	0.892
Blood level of C-peptide, ng/ml (T2D)	3.68 ± 1.80	8	NA	4.11 ± 2.28	6	NA
GLP-1 concentration in blood, pg/ml (no T2D) GLP-1 concentration in blood, pg/ml (T2D)	4.36 ± 3.76 1.33 ± 2.99	13 24	<0.001	5.36 ± 3.78 0.67 ± 1.74	13 19	<0.001
GIP concentration in blood, pg/ml (no T2D) GIP concentration in blood, pg/ml (T2D)	229.25 ± 211.60 318.46 ± 156.56	13 18	0.146	299.34 ± 168.77 403.29 ± 138.15	13 14	0.126
Blood level of leptin, ng/ml (no T2D)	86.28 ± 40.95	12	NA	48.03 ± 30.04	12	NA
Type of eating behavior, % Restrictive (no T2D) Restrictive (T2D) External (no T2D) External (T2D) Emotional (no T2D) Emotional (T2D)	78.6 100.0 85.7 50.0 100.0 50.0	14 18 14 18 14 18	0.073 0.061 0.002	50.0 94.4 71.4 38.9 78.6 44.4	14 18 14 18 14 18	0.010 0.087 0.075
Answers to appetite questions (only no T2D) How sated do you feel? How much do you want to eat? How much food could you eat now?	3.93 ± 3.47 8.14 ± 2.41 7.64 ± 2.90	14	NA	6.93 ± 3.71 5.07 ± 3.29 4.79 ± 3.47	14	NA

NA: Not applicable; T2D: Type 2 diabetes.

Figure 1. Relationship between percentage of body loss and baseline BMI value prior to treatment.

Figure 2. Relationship between an absolute hemoglobin A1c decrease and hemoglobin A1c prior the treatment.

Figure 3. Relationship between a relative hemoglobin A1c decrease and hemoglobin A1c prior the treatment.