Trans-femoral versus trans-carotid access for transcatheter aortic valve replacement: an updated systematic review and meta-analysis

Figures & data

Figure 1. PRISMA flowchart.

Table 1. Patient characteristics (dichotomous).

Patient characteristics (dichotomous)
Variables	Studies (n)	Events in TC group	Total number of patients (TC)	Events in TF group	Total number of patients (TF)	Odds ratio, M–H random, 95% CI	p-value	Heterogeneity (I^2) (%)
Males	7	894	1561	2758	5048	1.08 [0.86, 1.36]	0.48	61
Hypertension	6	980	1499	3723	4986	1.17 [0.85, 1.61]	0.34	56
COPD/chronic lung disease/respiratory faliure	6	418	1461	1174	4648	1.46 [0.96, 2.21]	0.08	85
Diabetes	7	542	1561	1677	5048	1.21 [1.04, 1.40]	0.01	16
Cerebrovascular disease	3	49	358	228	2160	1.43 [0.99, 2.08]	0.06	13
Peripheral vascular disease	7	868	1561	1464	5048	4.75 [1.55, 14.56]	0.006	98
NYHA functional class III/IV	5	303	520	1501	2622	1.02 [0.83, 1.25]	0.88	2
Stroke/TIA	5	158	1287	566	4145	0.87 [0.64, 1.18]	0.37	39
Prior cardiac surgery	2	282	1057	594	2932	1.46 [1.02, 2.09]	0.04	66
Permanent pacemaker implantation	3	151	1073	279	2075	1.01 [0.78, 1.29]	0.96	5
Atrial fibrillation	5	209	550	1233	3035	0.92 [0.76, 1.11]	0.39	0

Table 2. Patient characteristics (continuous).

Patient characteristics (continuous)
Variables	Studies (n)	Total number of patients (TC)	Total number of patients (TF)	Mean difference, IV, random, 95% CI	p-value	Heterogeneity (I^2) (%)
Age (years)	6	1434	4649	-0.89 [-1.41, -0.38]	0.0006	4
BMI	5	523	3036	-0.26 [-1.00, 0.48]	0.48	12
Creatinine	3	331	2161	-0.00 [-0.17, 0.17]	1.00	0
LVEF	6	1434	4649	-0.32 [-1.54, 0.89]	0.60	42
Aortic valvular mean gradient	4	1287	4145	-1.08 [-3.26, 1.10]	0.33	74
Aortic valve surface	5	1372	4587	-0.01 [-0.02, 0.00]	0.18	0

Figure 2. 30 day all-cause mortality forest plot.

Figure 3. Vascular complications forest plot.

Figure 4. Major bleeding forest plot.

Figure 5. Permanent pacemaker forest plot.

Figure 6. Cardiac tamponade forest plot.

Figure 7. 30 day stroke/TIA forest plot.

Figure 8. Hospital stay forest plot.