Marital status impacts survival of stage I non-small-cell lung cancer: a propensity-score matching analysis

Figures & data

Figure 1. The diagram of this study.

AJCC: American Joint Committee on Cancer; NSCLC: Non-small-cell lung cancer; SEER: Surveillance, Epidemiology and End Results.

Table 1. The baseline clinical characteristics of enrolled patients with stage I non-small-cell lung cancer before and after propensity-score matching.

Characteristic	Before propensity score matching			After propensity score matching
	Unmarried n = 6459 (%)	Married n = 7478 (%)	p-value	Unmarried n = 5289 (%)	Married n = 5290 (%)	p-value
Age	70 ± 10.3	69 ± 10.2	<0.001	69 ± 10.3	69 ± 9.6	0.373
– ≤70	3258 (50.4)	4251 (56.8)		2957 (55.9)	3011 (56.9)
– >70	3201 (49.6)	3227 (43.2)		2332 (44.1)	2279 (43.1)
Sex			<0.001			0.780
– Female	4375 (67.7)	3477 (46.4)		3228 (61.0)	3243 (61.3)
– Male	2084 (32.3)	4001 (53.6)		2061 (39.0)	2047 (38.7)
Race			<0.001			<0.001
– White	5188 (80.4)	6283 (83.9)		4200 (79.4)	4425 (83.6)
– Black	945 (14.6)	523 (7.0)		787 (14.9)	386 (7.3)
– Other	326 (5.0)	672 (9.1)		302 (5.7)	479 (9.1)
Laterality			0.616			0.937
– Left	2633 (40.8)	3017 (40.3)		2155 (40.7)	2160 (40.8)
– Right	3826 (59.2)	4461 (59.7)		3134 (59.3)	3130 (59.2)
Histology			<0.001			0.012
– Adenocarcinoma	3897 (60.2)	4745 (63.4)		3335 (63.1)	3386 (64.1)
– Squamous	1754 (27.3)	1818 (24.3)		1350 (25.5)	1235 (23.3)
– Other	808 (12.5)	915 (12.3)		604 (11.4)	669 (12.6)
Grade			<0.001			0.114
– I	1024 (15.9)	1432 (19.1)		946 (17.9)	1006 (19.1)
– II	2404 (37.2)	3048 (40.8)		2142 (40.5)	2071 (39.1)
– III	1558 (24.1)	1725 (23.1)		1246 (23.6)	1201 (22.7)
– IV	55 (0.9)	51 (0.7)		47 (0.9)	37 (0.7)
– Unknown	1418 (21.9)	1222 (16.3)		908 (17.2)	975 (18.4)
Stage			0.001			0.753
– IA	5472 (84.7)	6181 (82.7)		4425 (83.7)	4413 (83.4)
– IB	987 (15.3)	1297 (17.3)		864 (16.3)	877 (16.6)
Surgery			<0.001			0.775
– No	2240 (34.8)	1673 (22.4)		1420 (26.8)	1407 (26.6)
– Yes	4219 (65.2)	5805 (77.6)		3869 (73.2)	3883 (73.4)
Chemotherapy			0.022			0.317
– No	6162 (95.5)	7070 (94.5)		5047 (95.4)	5025 (95.0)
– Yes	297 (4.5)	408 (5.5)		242 (4.6)	265 (5.0)
Radiation			<0.001			0.675
– No	4698 (72.7)	6029 (80.6)		4094 (77.4)	4113 (77.8)
– Yes	1761 (27.3)	1449 (19.4)		1195 (22.6)	1177 (22.2)
Tumor size	20 ± 6.3	20 ± 6.3	0.025	20 ± 6.3	20 ± 6.2	0.669

Figure 2. Cancer-specific survival curve for cohort of patients with non-small-cell lung cancer according to the status.

(A) Marriage and (B) surgery after propensity-score matching.

CSS: Cancer-specific survival.

Table 2. Univariable and multivariable Cox regression analysis for cancer-specific survival.

Characteristics	Univariable analysis			Multivariable analysis
	HR	95% CI	p-value	HR	95% CI	p-value
Sex (female vs male)	1.828	1.722–1.940	<0.001	1.439	1.353–1.530	<0.001
Age (≤70 vs >70)	1.951	1.838–2.072	<0.001	1.541	1.448–1.641	<0.001
Race
– White	1	reference		1	reference
– Black	0.932	0.847–1.026	0.152	0.941	0.854–1.037	0.218
– Other	0.610	0.533–0.698	<0.001	1.541	1.448–1.641	<0.001
Laterality (right vs left)	0.929	0.874–0.986	0.016	0.971	0.914–1.032	0.342
Histology
– Adenocarcinoma	1	reference		1	reference
– Squamous	1.907	1.786–2.035	<0.001	1.411	1.319–1.509	<0.001
– Other	1.12	1.016–1.235	0.023	0.957	0.867–1.058	0.391
Differentiation (Grade I vs II vs III vs IV)	1.336	1.308–1.365	<0.001	1.070	1.044–1.097	<0.001
Stage (IA vs IB)	0.936	0.863–1.015	0.110
Surgery (no vs yes)	0.261	0.245–0.277	<0.001	0.293	0.263–0.325	<0.001
Chemotherapy (no vs yes)	1.538	1.362–1.737	<0.001	1.311	1.159–1.482	<0.001
Radiotherapy (no vs yes)	2.898	2.723–3.085	<0.001	0.744	0.673–0.822	<0.001
Marital status (unmarried vs married)	0.810	0.763–0.860	<0.001	0.811	0.763–0.861	<0.001
Tumor size (cm)	1.033	1.028–1.038	<0.001	1.019	1.014–1.024	<0.001

Figure 3. The proportion of the patients with non-small-cell lung cancer.

In (A) surgery, (B) chemotherapy and (C) radiotherapy according to marital status.

Figure 4. Kaplan–Meier survival curves.

(A) CSS in undergo surgery patients before PSM, (B) CSS in undergo surgery patients after PSM.

CSS: Cancer-specific survival; PSM: Propensity score matching.

Table 3. Multivariable Logistic regression analysis for different treatment according to marital status (method is enter selection).

Characteristics	Surgery			Chemotherapy			Radiotherapy
	OR	95% CI	p-value	OR	95% CI	p-value	OR	95% CI	p-value
Sex (female vs male)	0.777	0.717–0.841	<0.001	1.118	0.957–1.306	0.16	1.197	1.101–1.302	<0.001
Age (≤70 vs >70)	0.369	0.341–0.399	<0.001	0.549	0.467–0.645	<0.001	2.317	2.133–2.517	<0.001
Race
– White	1	reference		1	reference		1	reference
– Black	0.812	0.718–0.918	0.001	1.106	0.872–1.403	0.406	1.009	0.84–1.152	0.897
– Other	1.467	1.243–1.731	<0.001	0.947	0.702–1.277	0.719	0.519	0.43–0.628	<0.001
Laterality (right vs left)	1.093	1.010–1.182	0.026	1.022	0.875–1.194	0.784	0.895	0.825–0.972	0.008
Marital status (unmarried vs married)	1.841	1.698–1.995	<0.001	1.163	0.992–1.364	0.063	0.654	0.601–0.712	<0.001
Tumor size (cm)	0.966	0.960–0.972	<0.001	1.065	1.051–1.078	<0.001	1.026	1.020–1.033	<0.001