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Research Article

Titanium dioxide nanostructure-loaded Adriamycin surmounts resistance in breast cancer therapy: ABCA/P53/C-myc crosstalk

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Article: FSO979 | Published online: 20 Mar 2024

Figures & data

Table 1. Sequence of forward and reverse primers.

Table 2. Calcium concentration in breast cancer serum samples post treatment by Adriamycin and combination of both TiO2 and Adriamycin.

Table 3. Zinc concentration in breast cancer serum samples post treatment by Adriamycin and combination of both TiO2 and Adriamycin.

Figure 1. Effect of Adriamycin and combination of both TiO2 and Adriamycin against breast cancer in rat breast tissue on ABCA1 and ABCAG1 gene expression.

Data were expressed as means ± SD (n = 10). p < 0.05 is considered significant. Groups having the same letter are not significantly different from each other, while those having different letters are significantly different from each other.

Figure 1. Effect of Adriamycin and combination of both TiO2 and Adriamycin against breast cancer in rat breast tissue on ABCA1 and ABCAG1 gene expression.Data were expressed as means ± SD (n = 10). p < 0.05 is considered significant. Groups having the same letter are not significantly different from each other, while those having different letters are significantly different from each other.

Figure 2. Effect of Adriamycin and combination of both TiO2 and Adriamycin against breast cancer in rat breast tissue on P53 and Jak-2 gene expression.

Data were expressed as means ± SD (n = 10). The p < 0.05 is considered significant. Groups having the same letter are not significantly different from each other, while those having different letters are significantly different from each other.

Figure 2. Effect of Adriamycin and combination of both TiO2 and Adriamycin against breast cancer in rat breast tissue on P53 and Jak-2 gene expression.Data were expressed as means ± SD (n = 10). The p < 0.05 is considered significant. Groups having the same letter are not significantly different from each other, while those having different letters are significantly different from each other.

Figure 3. Effect of Adriamycin and combination of both TiO2 and Adriamycin against breast cancer in rat breast tissue on C-myc gene expression.

Data were expressed as means ± SD (n = 10). p < 0.05 is considered significant. Groups having the same letter are not significantly different from each other, while those having different letters are significantly different from each other.

Figure 3. Effect of Adriamycin and combination of both TiO2 and Adriamycin against breast cancer in rat breast tissue on C-myc gene expression.Data were expressed as means ± SD (n = 10). p < 0.05 is considered significant. Groups having the same letter are not significantly different from each other, while those having different letters are significantly different from each other.