Oleuropein impact on colorectal cancer

Figures & data

Figure 1. Estimated colorectum age-mortality worldwide rates in 2020.

Reproduced from http://gobocan.iarc.fr.

Table 1. Colorectal cancer US FDA approved immunotherapy.

Immunotherapy	Receptor	Target
Cetuximab	EGFR	Transmembrane protein
Bevacizumab or panitumumab	EGFR, VEGF/VEGFR	Transmembrane/signaling protein
Ziv-aflibercept or regorafenib or ramucirumab	VEGF/VEGFR	Signaling protein
Pembrolizumab or nivolumab or ipilimumab	Block PD-1	Programmed cell death protein 1

Table 2. Represent recent studies targeting colorectal cancer cytokine signaling pathways.

Cytokine	Potential therapy	Intervention
TNF	INCAGN01876 Vactosertib	Stimulation Inhibition
TGF	NIS7933, AP 12009 and anakinra	Inhibition
IL-1	CAN04
IL-7	NT-17, GM-CSF and leukine	Stimulation
GM-CSF	Sargramostim
IFN-γ	JX-594, GVAX and IFN-γ

Figure 2. Structures of some natural products drugs used in colorectal cancer.

Figure 3. The chemical structure of oleuropein.

Figure 4. Receptors involved in oleuropein action against colorectal cancer.