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Meta-Analysis

Low dose insulin infusion versus the standard dose in children with diabetic ketoacidosis: a meta-analysis

Mohamed Mohamed Belal1 Faculty of Medicine, Alexandria University, Alexandria, Egypt;2 Medical Research Group of Egypt (MRGE), Cairo, EgyptCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-8688-0349
ORCID Icon,
Basma Badrawy Khalefa2 Medical Research Group of Egypt (MRGE), Cairo, Egypt;3 Faculty of Medicine, Ain shams University, Cairo, EgyptORCID Iconhttps://orcid.org/0000-0002-8897-1682
ORCID Icon,
Eslam Mohammed Rabea1 Faculty of Medicine, Alexandria University, Alexandria, Egypt;2 Medical Research Group of Egypt (MRGE), Cairo, EgyptORCID Iconhttps://orcid.org/0000-0001-8464-3959
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Mazen Negmeldin Aly Yassin2 Medical Research Group of Egypt (MRGE), Cairo, Egypt;4 Faculty of Medicine, Helwan University, Cairo, EgyptORCID Iconhttps://orcid.org/0000-0002-9605-6548
ORCID Icon,
Mohamed Nabih Bashir1 Faculty of Medicine, Alexandria University, Alexandria, Egypt;2 Medical Research Group of Egypt (MRGE), Cairo, EgyptORCID Iconhttps://orcid.org/0000-0001-7363-5515
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Malak Mohamed Abd El-Hameed2 Medical Research Group of Egypt (MRGE), Cairo, Egypt;5 Faculty of Medicine, Zagazig University, Ash Sharqia, EgyptORCID Iconhttps://orcid.org/0000-0003-0542-0365
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Omar Elkoumi2 Medical Research Group of Egypt (MRGE), Cairo, Egypt;6 Faculty of Medicine, Suez University, Suez, EgyptORCID Iconhttps://orcid.org/0000-0003-1172-7574
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Saad Mohamed Saad1 Faculty of Medicine, Alexandria University, Alexandria, Egypt;2 Medical Research Group of Egypt (MRGE), Cairo, EgyptORCID Iconhttps://orcid.org/0000-0003-0341-077X
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Loubna Mohamed Saad1 Faculty of Medicine, Alexandria University, Alexandria, Egypt;2 Medical Research Group of Egypt (MRGE), Cairo, EgyptORCID Iconhttps://orcid.org/0000-0002-7181-4402
ORCID Icon &
Mohamed Hamouda Elkasaby2 Medical Research Group of Egypt (MRGE), Cairo, Egypt;7 Faculty of Medicine, Al-Azhar University, Cairo, EgyptORCID Iconhttps://orcid.org/0000-0003-1092-7144
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Article: FSO956 | Received 24 Jul 2023, Accepted 13 Dec 2023, Published online: 12 Apr 2024

Figures & data

Figure 1. PRISMA flow chart.

Figure 1. PRISMA flow chart.

Figure 2. Summary of risk of bias assessment of the included studies.

Figure 2. Summary of risk of bias assessment of the included studies.

Table 1. Summary of the included studies.

Table 2. Baseline characteristics of the enrolled patients in the included studies.

Figure 3. A Forest plot of the time to reach blood glucose ≤250 mg/dl.

Figure 3. A Forest plot of the time to reach blood glucose ≤250 mg/dl.

Figure 4. Forest plot of the time to resolution of acidosis (h).

Figure 4. Forest plot of the time to resolution of acidosis (h).

Figure 5. Forest plot of rate of blood glucose decrease until level is ≤250 mg per dl per hour.

Figure 5. Forest plot of rate of blood glucose decrease until level is ≤250 mg per dl per hour.

Figure 6. Forest plot of the incidence of hypokalemia.

Figure 6. Forest plot of the incidence of hypokalemia.

Figure 7. Forest plot of the incidence of hypoglycemia.

Figure 7. Forest plot of the incidence of hypoglycemia.

Figure 8. Forest plot of the incidence of treatment failure.

Figure 8. Forest plot of the incidence of treatment failure.

Figure 9. Forest plot of the incidence of cerebral edema.

Figure 9. Forest plot of the incidence of cerebral edema.
Supplemental material

Supplementary Tables S1-S2

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