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Research Article

Systematic exploration of network pharmacology, in silico modeling and pharmacokinetic profiling for vitamin E in polycystic ovarian syndrome

ORCID Icon & ORCID Icon
Article: FSO952 | Received 18 Oct 2023, Accepted 07 Dec 2023, Published online: 17 Apr 2024

Figures & data

Figure 1. Swiss target prediction for vitamin E.

Figure 1. Swiss target prediction for vitamin E.

Figure 2. Venn diagram.

Figure 2. Venn diagram.

Figure 3. Interactions between proteins encoded by genes.

Figure 3. Interactions between proteins encoded by genes.

Table 1. Network topological parameters of top ten target genes.

Figure 4. Gene ontology enrichment analysis (BP-biological process, CC-cellular components and MF molecular function).

Figure 4. Gene ontology enrichment analysis (BP-biological process, CC-cellular components and MF molecular function).

Figure 5. KEGG enrichment analyses.

Figure 5. KEGG enrichment analyses.

Figure 6. Compound target disease network.

Figure 6. Compound target disease network.

Table 2. Interpretation of in silico activity of vitamin E on PCOS.

Table 3. Pharmacokinetic profile of Vitamin E.

Table 4. Physicochemical properties of Vitamin E with swiss ADME.

Table 5. Assessing vitamin E's lipophilicity profile with Swiss ADME.

Table 6. Assessing vitamin E's Water solubility profile with swiss ADME.

Table 7. Assessing vitamin E's toxicity profile with OSIRIS.

Table 8. Prediction of biological activity of vitamin E with PASS online.

Table 9. Bioactivity score of Vitamin E using molinspiration.