Computational drug–drug interaction prediction mediated by CYP450 isoforms of Ilaprazole coadministered with clopidogrel

Figures & data

Figure 1. Drug–drug interaction prediction for Ilaprazole and clopidogrel mediated by CYP450 isoforms.

Table 1. Probability of overlapping CYP450 activities of Ilaprazole and Clopidogrel.

CYP450 isoforms	Inhibitor (ΔP)		Substrate (ΔP)		Inducer (ΔP)
Drug	Clopidogrel	Ilaprazole	Clopidogrel	Ilaprazole	Clopidogrel	Ilaprazole
CYP2C19	0.109	0.72	0.538	0.709	-	-
CYP3A4	-	0.393	0.242	0.593	-	0.722
CYP2C9	0.019	0.561	0.822	0.682	-	-
CYP2D6	-	0.153	-	0.2	-	-
CYP1A2	-	-	-	0.761	-	0.905

Table 2. Drug–drug interaction prediction for clopidogrel and various proton pump inhibitors mediated by CYP450 isoforms.

Drug combination	Interaction on isoforms of Cytochrome P450 (ΔP)
	CYP1A2	CYP2B6	CYP2C19	CYP2C8	CYP2C9	CYP2D6	CYP3A4
Clopidogrel + Ilaprazole	-0.161	-0.04	0.955	-0.095	-0.475	-0.243	-0.714
Clopidogrel + Pantoprazole	-0.122	-0.089	0.929	-0.256	-0.594	-0.218	-0.772
Clopidogrel + Omeprazole	-0.137	-0.052	0.96	-0.177	-0.364	-0.168	-0.805
Clopidogrel + Esomeprazole	-0.137	-0.052	0.96	-0.177	-0.364	-0.168	-0.805
Clopidogrel + Lansoprazole	-0.212	0.063	0.962	-0.111	-0.556	-0.353	-0.859
Clopidogrel + Rabeprazole	-0.148	0.055	0.959	-0.045	-0.552	-0.314	-0.848
Clopidogrel + Dexlansoprazole	-0.212	0.063	0.962	-0.111	-0.556	-0.353	-0.859
Clopidogrel + Dexrabeprazole	-0.148	0.055	0.959	-0.045	-0.552	-0.314	-0.848