One-step nucleic acid amplification: the possible value in assessing sentinel lymph node metastasis during mastectomy

Figures & data

Table 1 Summary of data comparing OSNA with routine histopathological examination in detecting positive SLN

Study	Year	Number of lymph nodes	Sensitivity (%)	Specificity (%)	Positive predictive value (%)	Negative predictive value (%)	Concordance rate (%)
Tsujimoto et al^Citation15	2007	325	95.8	98.6	91.5	99.3	98.2
Tamaki et al^Citation17	2009	450	87.5	94.1	76.1	97.2	92.9
Feldman et al^Citation18	2011	1044	77.5	95.8	73.8	96.6	93.4
Snook et al^Citation16	2011	395	91.7	96.9	86.8	98.1	95.9
Wang et al^Citation19	2012	1188	83.7	92.9	96.8	69.1	91.4
Buglioni et al^Citation20	2013	903	92.6	96.1	86.1	98.0	95.3
Banerjee et al^Citation21	2014	268	95.1	95.6	80.0	99.1	95.5
Chaudhry et al^Citation22	2014	166	92.8	93.7	43.4 macro-metastases only	99.2	89.2

Abbreviations: OSNA, one-step nucleic acid amplification; SLN, sentinel lymph node.

Figure 1 Best evidence management of the axilla in patients with newly diagnosed breast cancer.

Abbreviations: LN, lymph node; mets, metastases; WLE, wide local excision; Mx, mastectomy; NAC, neoadjuvant chemotherapy; LVI, lymphovascular invasion; Pre-Rx, pre-therapy; MDT, multidisciplinary team meeting; ALND, axillary lymph node dissection; OSNA, one-step nucleic acid amplification; SLN, sentinel lymph node; dx, disease.

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