Effect of reduced dietary fat on estradiol, adiponectin, and IGF-1 levels in postmenopausal women with breast cancer

Figures & data

Table 1 Differences between anthropometric and clinical parameters in breast cancer diagnosed women with reduced dietary fat (Group 1) and dietary recommendations (Group 2)

Clinical parameter	Group 1 initial	Group 1 final	Group 2 initial	Group 2 final	p
Age (years)	50.45 ± 7.94		52.26 ± 6.11		>0.05
BMI (kg/m^2)	27.93 ± 4.45	26.05 ± 2.65*	28.83 ± 4.60	28.74 ± 3.10**	0.01* 0.90**
Overweight: 25–26.9 kg/m^2	8 (15.3%)	11 (23.0%)
Obesity grade 1: 27–29.9 kg/m^2	31 (61.5%)	31 (61.5%)
Obesity grade 2: 30–39.9 kg/m^2	11 (23.0%)	8 (15.3%)
Waist circumference (cm)	99.92 ± 11.05	91.59 ± 9.59*	95.03 ± 10.73	94.00 ± 9.89**	*0.0001 **0.61
Clinical stage, n (%)
II	23 (46%)		26 (52%)
III	27 (54%)		24 (48%)
Histologic type, n (%)
Ductal	27 (54%)		30 (60.00%)
Lobar	13 (26%)		15 (31.00%)
Others	10 (20%)		5 (9.00%)
Hormonal receptors positive
Estrogen	99%		99%
Progesterone	98%		98%

Note:

* Initial vs final Group 1;

** initial vs final Group 2.

Abbreviation: BMI, body mass index.

Table 2 Effects of reduced dietary fat (Group 1) on adiponectin, estradiol, and IGF-1 in serum

Metabolic profile	Group 1 initial	Group 1 final	p
Estradiol (ng/mL)	21.23 ± 14.32	16.05 ± 10.25	0.003
Testosterone (ng/mL)	0.23 ± 0.14	0.19 ± 0.17	0.07
Adiponectin (µg/mL)	47.53 ± 12.19	42.52 ± 12.34	0.004
IGF-1 (UI)	69.29 ± 39.91	63.57 ± 35.77	0.45
Glucose (mg/dL)	96.71 ± 4.94	89.56 ± 9.91	0.0001