Protein expression profile and microRNA expression signature in estrogen receptor-positive and -negative breast cancers: report of two cases

Figures & data

Figure 1 Venn diagram of identified proteins from ER-positive and -negative breast cancer tissues.

Notes: A total of 123 proteins were identified in ER-positive and 177 in ER-negative tumors. About 98 proteins were common to both ER-positive and -negative tumors. The total number of identified proteins was 202.
Abbreviation: ER, estrogen receptor.

Table 1 The identified unique proteins in ER-positive breast cancer tissues on the biological process

Biological process	Identified proteins
Cell growth (n=7)	Anterior gradient protein 2 homolog precursor
	Activated RNA polymerase transcriptional coactivator p15
	Heterogeneous nuclear ribonucleoprotein F
	Thymidine phosphorylase precursor
	Thioredoxin
	Prolactin-inducible protein precursor
	Heterogeneous nuclear ribonucleoprotein U
Cytoskeletal activities (n=5)	Decorin precursor
	Collagen alpha-1 (XIV) chain precursor
	LIM and SH3 domain protein 1
	Glutathione S-transferase
	Receptor expression-enhancing protein 6
Protein catabolism (n=5)	Inter-alpha-trypsin inhibitor heavy chain H1 precursor
	Lysosome-associated membrane glycoprotein 2 precursor
	Serpin B6
	Kelch-like protein 31
	Flavin reductase
Fatty acid metabolism (n =5)	Fatty acid synthase
	Apolipoprotein A-I precursor
	Zic-alpha-2-glycoprotein precursor
	Platelet-activating factor acetylhydrolase IB
	Acid ceramidase precursor
Others (n=3)	Adenylate kinase isoenzyme 1
	Arylamine N-acetyltransferase 1
	Fructose-1,6-bisphosphatase 1

Note: Activated RNA polymerase transcriptional coactivator p15.

Figure 2 Changes of microRNA expression for fatty acid synthase in ER-positive and -negative breast cancer tissues.

Notes: The expressions of miR-27a, miR-107, miR-181a, and miR-195 were showed as a ratio of ΔΔCT value (ER-positive/ER-negative breast cancer tissue).
Abbreviation: ER, estrogen receptor.