A single-nucleotide polymorphism of the beta 2-adrenergic receptor gene can predict pathological complete response to taxane- and platinum-based neoadjuvant chemotherapy in breast cancer

Figures & data

Table 1 Detailed information of primers in the study

SNP	Primer1	Primer2	Extension of primer	Single-base primer
Rs1042713	ACGTTGGATGACCCAC	ACGTTGGATGAGCGCCTT	R	ACGTTGGATGAGCGCCTT
	ACCTCGTCCCTTT	CTTGCTGGCA		CTTGCTGGCA

Abbreviation: SNP, single-nucleotide polymorphism.

Table 2 Associations between genotypes of rs1042713 and ER in patients with locally advanced breast cancer

SNPs	Model	Genotype	ER positive	ER negative	χ^2	P-value
rs1042713	Codominant	AA	45 (46.4)	10 (30.3)	3.503	0.174
		AG	38 (39.2)	19 (57.6)
		GG	14 (14.4)	4 (12.1)
	Dominant	AA	45 (46.4)	10 (30.3)	2.611	0.106
		AG+GG	52 (53.6)	23 (69.7)
	Recessive	AA+AG	83 (85.6)	29 (87.9)	0.110	0.740
		GG	14 (14.4)	4 (12.1)
	Overdominant	AA+GG	59 (60.8)	14 (42.4)	3.386	0.066
		AG	38 (39.2)	19 (57.6)

Abbreviations: ER, estrogen receptor; SNP, single-nucleotide polymorphism.

Figure 1 The relationship between genotypes of rs1042713 and pCR in patients with BC, luminal type BC and HER2-positive BC.

Abbreviations: BC, breast cancer; pCR, pathological complete response.

Table 3 Associations between genotypes of rs1042713 and pCR after neoadjuvant chemotherapy in patients with locally advanced breast cancer

SNPs	Model	Genotype	pCR	Non-pCR	OR (95% CI)a	P-value
rs1042713	Codominant	AA	10 (18.2)	45 (81.8)	1.00
		AG	22 (38.6)	35 (61.4)	2.92 (0.96–8.87)	0.059
		GG	7 (38.9)	11 (61.1)	2.87 (0.65–12.71)	0.165
	Dominant	AA	10 (18.2)	45 (81.8)	1.00
		AG+GG	29 (38.7)	46 (61.3)	2.91 (1.02–8.29)	0.046b
	Recessive	AA+AG	32 (28.6)	80 (71.4)	1.00
		GG	7 (38.9)	11 (61.1)	1.63 (0.43–6.19)	0.471
	Overdominant	AA+GG	17 (23.3)	56 (76.7)	1.00
		AG	22 (38.6)	35 (61.4)	1.63 (0.43–6.19)	0.129

Notes:

a OR and 95% CI was analyzed by logistic regression and adjusted by age, menses status, ER, PR, and HER2 status. Common genotype was taken as reference.

b P<0.05.

Abbreviations: pCR, pathological complete response; SNP, single-nucleotide polymorphism.