Breast Cancer Adjuvant Radiotherapy in BRCA1/2, TP53, ATM Genes Mutations: Are There Solved Issues?

Figures & data

Table 1 Effects of ART Issues in BC Related to TSGs Mutations as Summarized in This Review

ART Issues	BC-BRCA1/2mts	BC-TP53mts	BC-ATMmts
RT sensitivity	No difference	Negative effect	Depending on mts status
Toxicity	No difference	Unknown*	Based on mts type and combination
SPMs incidence	Not increased	Increased	Not reported
CBC incidence	Increased in deleterious mts **	Not reported	Not increased
Safety in ART use	Caution in deleterious mts **	No	Depending on mts status

Notes: *Toxicity is unknown due to limited data and in vitro experiences.^65,67 **Deleterious mutation according the BIC criteria as reported in the WECARE study.^96,97

Abbreviations: ART, adjuvant radiotherapy; BC, breast cancer; TSGs, tumor suppressor genes; mts, mutations; RT, radiotherapy; SPMs, secondary primary malignancies; CBC, contralateral breast cancer.

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