Figures & data
Figure 1 Breast tumor progression.
![Figure 1 Breast tumor progression.](/cms/asset/f428248e-ca42-43a8-bdc1-e51f8104b547/dbct_a_24648766_f0001_c.jpg)
Figure 2 Polarity complexes in epithelial cells.
Abbreviations: Amot, angiomotin; aPKC, atypical protein kinase C; cdc42, cell division control protein 42; Crb, Crumbs 3; Dlg, Discs-large; Lgl, lethal giant larvae; Lkb1, liver kinase b1; Patj, Pals1-associated tight junction protein; Scrib, Scribble.
![Figure 2 Polarity complexes in epithelial cells.](/cms/asset/a33038fb-25b5-45e6-b22a-3e28b684c5d8/dbct_a_24648766_f0002_c.jpg)
Figure 3 Potential mechanisms by which normal epithelial organization can be lost early in the progression of breast cancer.
Abbreviations: EMT, epithelial-mesenchymal transition; MET, mesenchymal-epithelial transition.
![Figure 3 Potential mechanisms by which normal epithelial organization can be lost early in the progression of breast cancer.](/cms/asset/7170027c-f231-4bee-bae7-7da4fa4b290d/dbct_a_24648766_f0003_c.jpg)
Figure 4 Model for oriented cell division.
Abbreviations: aPKC, atypical protein kinase C; cdc42, cell division control protein 42; Dlg, Discs-large; E-cad, E-cadherin; LGN, Leu-Gly-Asn repeat-enriched protein; NuMA, nuclear mitotic apparatus protein; MT, microtubule; Gαi, guanine nucleotide binding protein alpha inhibitory 1.
![Figure 4 Model for oriented cell division.](/cms/asset/ed021332-1886-40c3-be03-1a6ff566c56c/dbct_a_24648766_f0004_c.jpg)
Figure 5 Signaling pathways regulated by apical–basal polarity complexes.
Abbreviations: Bim, Bcl-2 interacting mediator of cell death; Crb, Crumbs 3; c-Jun, cellular Jun; ECM, extracellular matrix; HER2, human epidermal growth factor receptor 2; Jak, Janus kinase; JNK, c-Jun N-terminal kinase; Lkb1, liver kinase b1; MAPK, mitogen activated protein kinase; MMP, matrix metalloproteinase; PI3K, phosphatidylinositide 3-kinase; RhoA, Ras homolog gene family member A; Scrib, Scribble; Stat, signal transducer and activator of transcription; TGF, transforming growth factor.
![Figure 5 Signaling pathways regulated by apical–basal polarity complexes.](/cms/asset/b8c57ddd-6101-4304-8572-3cd9cd1d2cd1/dbct_a_24648766_f0005_c.jpg)
Figure 6 Regulation of Hippo-Yap1/Taz signaling by polarity complexes. The apical Crumbs and lateral Scrib complexes can sequester Yap1/Taz and the Hippo pathway kinases to prevent proliferation in polarized epithelial cells (left). Loss of polarity inactivates the Hippo pathway and releases Yap1/Taz to enter the nucleus to regulate proliferation (right). The Crumbs complex can also regulate SMADs to sensitize cells to epithelial-mesenchymal transition.
![Figure 6 Regulation of Hippo-Yap1/Taz signaling by polarity complexes. The apical Crumbs and lateral Scrib complexes can sequester Yap1/Taz and the Hippo pathway kinases to prevent proliferation in polarized epithelial cells (left). Loss of polarity inactivates the Hippo pathway and releases Yap1/Taz to enter the nucleus to regulate proliferation (right). The Crumbs complex can also regulate SMADs to sensitize cells to epithelial-mesenchymal transition.](/cms/asset/6cdcd43d-e4f5-4a6b-9c86-bcf289402206/dbct_a_24648766_f0006_c.jpg)