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Breast Cancer: Targets and Therapy Volume 16, 2024 - Issue
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SHORT REPORT

Role of AURKB Inhibition in Reducing Proliferation and Enhancing Effects of Radiotherapy in Triple-Negative Breast Cancer

Sierra Pellizzari1 Department of Anatomy and Cell Biology, Western University, London, ON, Canada
,
Harjot Athwal1 Department of Anatomy and Cell Biology, Western University, London, ON, Canada
,
Anne Claudine Bonvissuto1 Department of Anatomy and Cell Biology, Western University, London, ON, Canada;2 Verspeeten Family Cancer Centre, London Health Sciences Centre, London, ON, Canada
&
Armen Parsyan1 Department of Anatomy and Cell Biology, Western University, London, ON, Canada;2 Verspeeten Family Cancer Centre, London Health Sciences Centre, London, ON, Canada;3 Department of Oncology, Western University, London, ON, Canada;4 Department of Surgery, St Joseph’s Health Care and London Health Sciences Centre, Western University, London, ON, CanadaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-0084-8733
ORCID Icon
Pages 341-346 | Received 17 Oct 2023, Accepted 04 Jun 2024, Published online: 09 Jul 2024

Figures & data

Figure 1 Effects of single agent AZD1152 at increasing concentrations on colony formation in TNBC cell lines. Dose response curves were generated for AZD1152 in studied cell lines. IC50 values were determined using a nonlinear regression model in GraphPad Prism software.

Abbreviation: SF, Surviving Fraction.
Figure 1 Effects of single agent AZD1152 at increasing concentrations on colony formation in TNBC cell lines. Dose response curves were generated for AZD1152 in studied cell lines. IC50 values were determined using a nonlinear regression model in GraphPad Prism software.

Figure 2 Effects of AZD1152 in combination with RT in TNBC cell lines. Combination treatment of (A) MDA-MB-231; (B) MDA-MB-468; (C) SUM159 cells with a single concentration of AZD1152 and a single dose of RT. Treatment with RT or AZD1152 alone results in reduced colony formation with further significant reduction of proliferation by a combination treatment relative to single agent treatment (p≤0.05 compared to control (*), RT only (⍺) or (β) AZD1152 only treatment); (D) Synergy plot using various concentrations of AZD1152 and doses of RT in MDA-MB-231 cells using SynergyFinder, where the intensity of red indicates a higher degree of synergy (n = 3).

Abbreviation: SF, Surviving Fraction.
Figure 2 Effects of AZD1152 in combination with RT in TNBC cell lines. Combination treatment of (A) MDA-MB-231; (B) MDA-MB-468; (C) SUM159 cells with a single concentration of AZD1152 and a single dose of RT. Treatment with RT or AZD1152 alone results in reduced colony formation with further significant reduction of proliferation by a combination treatment relative to single agent treatment (p≤0.05 compared to control (*), RT only (⍺) or (β) AZD1152 only treatment); (D) Synergy plot using various concentrations of AZD1152 and doses of RT in MDA-MB-231 cells using SynergyFinder, where the intensity of red indicates a higher degree of synergy (n = 3).

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