Preserving fertility in patients undergoing treatment for breast cancer: current perspectives

Figures & data

Table 1 Success with assisted reproductive technologies in the USA in 2011

Age group, years	Percentage of IVF cycles using nondonor eggs resulting in pregnancy	Percentage of IVF cycles using nondonor eggs resulting in live birth	Percentage of transfers of frozen embryos resulting in live birth
<35 years	46.1	40.0	39.0
35–37 years	38.5	31.9	35.5
38–40 years	29.2	21.5	29.7
41–42 years	19.4	12.1	24.0
43–44 years	10.7	5.3	17.0
>44 years	4.1	1.1	14.8

Note: Success rates are based on 151,923 cycles.²⁰

Abbreviation: IVF, in vitro fertilization.

Table 2 Effect of chemotherapy on ovarian follicles^34,35

Chemotherapeutic agent	Toxic effect	Result
Alkylating agents, topoisomerase inhibitors	Apoptotic cell death via induction of breaks in double-stranded DNA	Diminution of ovarian reserve
Antimetabolites	Damage of proliferating granulosa cells	Transient amenorrhea, no alteration of ovarian reserve
Taxanes	Uncertain	Uncertain

Centers for Disease Control and Prevention, American Society for Reproductive Medicine, Society for Assisted Reproductive Technology2011 Assisted Reproductive Technology Fertility Clinic Success Rates ReportAtlanta, GA, USAUS Dept of Health and Human Services2013 Available from: http://www.cdc.gov/art/ART2011/PDFs/ART_2011_Clinic_Report-Full.pdfAccessed May 31, 2014

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Rodriguez-WallbergKAOktayKFertility preservation and pregnancy in women with and without BRCA mutation-positive breast cancerOncologist201217111409141723006497

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SonmezerMOktayKFertility preservation in young women undergoing breast cancer therapyOncologist200611542243416720842

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