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Review

Role of trastuzumab emtansine in the treatment of HER2-positive breast cancer

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Pages 103-113 | Published online: 23 Jul 2014

Figures & data

Figure 1 Mechanism of action of T-DM1

Notes: (1) Trastuzumab retains all of its mechanisms of action. It delivers the DM1 chemotherapy directly and specifically to the HER2-positive breast cancer cell. (2) T-DM1 is internalized into the HER2-positive breast cancer cell. (3) DM1 is released once inside the cell. DM1 is a very potent chemotherapy agent that inhibits tubulin development of the mitotic spindle and cell division.
Abbreviations: DM1, emtansine; HER2, human epidermal growth factor receptor 2; T-DM1, trastuzumab emtansine.
Figure 1 Mechanism of action of T-DM1

Table 1 Summary of Phase I clinical trials

Table 2 Summary of Phase II clinical trials

Table 3 Summary of clinical trials currently underway