Triple negative breast cancer: an Indian perspective

Figures & data

Video abstract

Table 1 Showing comparison of menopausal status

Menopausal status	TNBC	Others	Total
Premenopausal	18 (48.64%)	32 (66.66%)	50
Postmenopausal	19 (51.36%)	16 (33.33%)	35
Total	37	48	85

Note: Chi-square 2.80, P=0.009.

Abbreviation: TNBC, triple negative breast cancer.

Table 2 Comparison of risk factors in TNBC and others

Risk factors	Triple negative	N	Mean	P-value	95% CI
Age	TNBC	37	48.41	0.26	−7.88–02.19
	Others	48	51.25	(NS)
Age at menarche	TNBC	37	15.08	0.447	−0.834–0.371
	Others	48	15.31	(NS)
Total reproductive age	TNBC	37	27.43	0.845	−3.08–2.531
	Others	48	27.71	(NS)
Age at first child birth	TNBC	37	21.41	0.220	−4.215–0.984
	Others	48	23.02	(NS)

Note: Statistics by Student’s t-test.

Abbreviations: TNBC, triple negative breast cancer; CI, confidence interval; NS, not significant.

Table 3 Showing comparison of tumor size

Size	TNBC	Others	Total
<5 cm	6	24	30
>5 cm	31	24	55
Total	37	48	85

Note: Chi-square 9.01, P=0.011.

Abbreviation: TNBC, triple negative breast cancer.

Table 4 Showing comparison of disease stage

Type	TNBC	Others	Total
LABC	26	27	53
EBC	5	19	24
Total	31	46	77

Note: Chi-square 5.47, P=0.01.

Abbreviations: TNBC, triple negative breast cancer; LABC, locally advanced breast cancer; EBC, early breast cancer.

Table 5 Showing comparison of axillary lymph node status

Lymph node	TNBC	Others	Total
Present	27	29	56
Absent	10	19	29
Total	37	48	85

Note: Chi-square 0.960, P=0.3271.

Abbreviation: TNBC, triple negative breast cancer.

Table 6 Showing comparison of Nottingham histological grade

Nottingham grade	TNBC	Others	Total
1 and 2	13	35	48
3	24	13	37
Total	37	48	85

Note: Chi-square 12.13, P=0.0004.

Abbreviation: TNBC, triple negative breast cancer.

Table 7 Showing comparison of local recurrence

Recurrence	TNBC	Others	Total
No recurrence	29	46	75
Recurrence	2	0	2
Total	31	46	77

Notes: Fisher’s exact test, P=0.1589. Advanced breast cancer cases excluded n=8.

Abbreviations: TNBC, triple negative breast cancer; ABC, advanced breast cancer.

Table 8 Showing comparison of short-term survival

Survival	TNBC	Others	Total
DFS	34	48	82
Death	3	0	3
Total	37	48	85

Note: Fisher’s exact test, P=0.07.

Abbreviations: TNBC, triple negative breast cancer; DFS, disease free survival.

Table 9 Showing prevalence of TNBC worldwide

Author	Year	Country	Number of cases	Prevalence (%)
Dunnwald et al^Citation7	2007	USA	155,175	25
Bauer et al^Citation17	2007	USA	92,358	12.5
Rakha et al^Citation8	2007	UK	1,726	16.3
Onitilo et al^Citation9	2009	USA	1,134	13.4
Ambroise et al^Citation13	2011	India	2,001	29.8
Ma et al^Citation19	2012	Hong Kong	1,800	12
Li et al^Citation20	2013	People’s Republic of China	21,749	12.18
Somali et al^Citation16	2013	Turkey	882	15
Zubeda et al^Citation14	2013	India	619	46
Sharma et al^Citation12	2014	India	972	31.9
Present study	2015	India	85	43.5

Abbreviation: TNBC, triple negative breast cancer.

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