Pharmacologic management of bone-related complications and bone metastases in postmenopausal women with hormone receptor-positive breast cancer

Figures & data

Table 1 Summary of compounds in development for the management of bone-related complications and bone metastases in postmenopausal women with hormone receptor-positive breast cancer

Agent	Clinical trial identifier	Phase	Design	End points	Status
mTOR inhibitor
Everolimus	EVE NCT01626222	IIIb	EVE+EXE vs PBO+EXE in patients with ABC or MBC	Primary: ORR Exploratory: Bone turnover markers	Completed
Tyrosine kinase inhibitors
Cabozantinib	NCT01441947	II	CAB+FUL in HR+ BC that has spread to the bone	Primary: Bone imaging response rate Secondary: Bone turnover	Ongoing
Dasatinib	NCT00754325	II	DAS+FUL vs FUL in patients with ABC	Primary: PFS Secondary: Change in bone markers, effect on bone pain, BMD changes	Completed
Dasatinib	NCT00696072	II	DAS+LET vs LET in MBC	Primary: CBR Secondary: Change in bone markers, effect on bone pain, BMD changes	Completed
Vandetanib	NCT00811369	II	VAN+FUL vs PBO+FUL in patients with bone only or bone-predominant HR+ MBC	Primary: Change in NTx level	Completed

Abbreviations: ABC, advanced breast cancer; BC, breast cancer; BMD, bone mineral density; CAB, cabozantinib; CBR, clinical benefit rate; DAS, dasatinib; EVE, everolimus; EXE, exemestane; FUL, fulvestrant; HR+, hormone receptor-positive; LET, letrozole; MBC, metastatic breast cancer; mTOR, mammalian target of rapamycin; NTx, N-terminal telopeptide; ORR, overall response rate; PBO, placebo; PFS, progression-free survival; VAN, vandetanib.