Current understanding of the role and regulation of miRNAs in Burkitt lymphoma

Figures & data

Figure 1 An overview of MYC–miRNA regulatory loop and related pathways.

Note: miRNAs upregulated by Myc are indicated by the red arrow and the downregulated miRNAs are indicated by the blue arrow.

Figure 2 An overview of the pathways affected by Myc-regulated miRNAs.

Notes: (A) Myc-induced miRNAs and their regulated pathways. EBV-encoded miRNAs may compete with the miR-17-92 cluster for regulation of the same target genes. (B) Myc-repressed miRNAs and their regulated pathways. EBV-encoded BARTs may compete with cellular miR-29 family members.

Abbreviation: EBV, Epstein–Barr virus.

Table 1 List of miRNAs reported to be downregulated in BL

Downregulated miRNAs	References
hsa-miR-221, hsa-miR-155, hsa-miR-146a, hsa-miR-146b-5p, hsa-miR-26b, hsa-miR-23a, hsa-miR-30d, hsa-miR-107, hsa-miR-103, hsa-miR-222, hsa-miR-26a, hsa-miR-30a, hsa-miR-142-5p, hsa-miR-23b, hsa-miR-342-3p, hsa-miR-29b, hsa-miR-34b	^Citation13
hsa-let-7a, hsa-miR-34b	^Citation57
hsa-miR-9*	^Citation58
hsa-miR-29a, hsa-miR-29b	^Citation15
hsa-155, hsa-196b, hsa-885-5p, hsa-222, hsa-135b, hsa-21, hsa-31, hsa-708, hsa-23a, hsa-455-5p, hsa-455-3p, hsa-29b, hsa-29c, hsa-342-5p, hsa-146a, hsa-150	^Citation72
hsa-513, hsa-18b, hsa-15b, hsa-454-3p, hsa-148a, let-7f, hsa-98, hsa-363, hsa-582, hsa-146, hsa-155, let-7d, hsa-26b, hsa-29b, hsa-142-3p, hsa-16, hsa-15a, hsa-590, hsa-32, hsa-331, hsa-138, hsa-28	^Citation70
hsa-miR-664-3p, hsa-miR-664-5p, hsa-miR-150-3p, hsa-miR-150-5p, hsa-miR-155-5p, hsa-miR-184, hsa-miR-196b-5p, hsa-miR-151b, hsa-miR-211-5p, hsa-miR-221-3p, hsa-miR-29c-5p	^Citation73
hsa-miR-155	^Citation74^–^Citation76

Abbreviation: BL, Burkitt lymphoma.

Table 2 List of miRNAs reported to be upregulated in BL

Upregulated miRNAs	References
hsa-miR-371-5p, hsa-miR-185, hsa-miR-93*, hsa-miR-326, hsa-miR-497, hsa-miR-26b*, hsa-miR-339-5p, hsa-miR-485-3p, hsa-miR-9, hsa-miR-193a-5p, hsa-miR-448, hsa-miR-202*, hsa-miR-483-3p, hsa-miR-26a-1*, hsa-miR-328, hsa-miR-192, hsa-miR-429, hsa-miR-324-5p, hsa-miR-340, hsa-miR-105*, hsa-miR-124*	^Citation13
hsa-miR-17-92	^Citation42
hsa-miR-513a-5p, hsa-miR-628-3p	^Citation15
hsa-296-5p, hsa-296-3p, hsa-130b, hsa-18a, hsa-18b, hsa-19a, hsa-19b, hsa-20a, hsa-20b, hsa-17, hsa-106	^Citation72
hsa-202, hsa-92, hsa-19a, hsa-19b, hsa-296, hsa-663, hsa-22, hsa-320, hsa-181b, hsa-422b, hsa-484	^Citation70
hsa-miR-17-3p, hsa-miR-18a-3p, hsa-miR-19a-3p, hsa-miR-20a-3p, hsa-miR-25-5p, hsa-miR-93-3p, hsa-miR-106b-3p, hsa-miR-106b-5p, hsa-miR-130b-3p, hsa-miR-296-3p, hsa-miR-335-3p, hsa-miR-339-5p, hsa-miR-573, hsa-miR-4521	^Citation73
hsa-miR-21, hsa-miR-23a	^Citation100

Abbreviation: BL, Burkitt lymphoma.

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