The role of rose hip (Rosa canina L) powder in alleviating arthritis pain and inflammation – part II animal and human studies

Figures & data

Figure 1 Ripe frozen berries from Rosa canina L. are shown in the left panel and ripe frozen berries cut through with visible seeds are shown in the right panel.

Figure 2 Effect size of paracetamol, glucosamine, and rose hip on pain is given.

Note: Data extracted from Christiansen et al.²⁶
Abbreviation: ns, not significant.

Table 1 The difference in clinical outcome from two different versions of rose hip powder, combined seed and shell and pure shell powder is given

	Seed/shell	Shells
Effect on pain in placebo controlled RCT trials^Citation5,Citation10^–^Citation12	++++	–
Effect on stiffness in placebo controlled RCT trials^Citation10^–^Citation12	+++	–
Effect on ADL in placebo controlled RCT trials^Citation5,Citation10^–^Citation12	++++	–
Patients’ preferences to treatment in placebo controlled RCT trials^Citation10	+	–
Patients’ positive response rate in favor of active treatment vs placebo^Citation10^–^Citation12	+++	–
Impact on symptoms of rheumatism^Citation5	+	–
Anti–inflammatory (from blood samples)^Citation5,Citation29,Citation42	+++	–
Anti–inflammatory (from clinical observation)^Citation5	+	–
Dose-dependency^Citation42,Citation44,Citation45	+++	–
Positive impact on cholesterol^Citation10	+	–
Meta-analysis^Citation26	+	–
Effect size^Citation26	+	–
Reduction in rescue medication^Citation10,Citation11	++	–
Protect from gastrointestinal damage^Citation5,Citation7,Citation10^–^Citation12	+	(+)
Side effects^Citation5,Citation10^–^Citation12,Citation33	–	(+)
Improvement on gait analysis (not tested on “seed/shell” products)^Citation49	–	+

Note: + Indicates positively reported and - indicates not reported.

Abbreviations: ADL, activity of daily living; RCT, randomized clinical trial.

Christensen R, Bartels EM, Altman RD, Astrup A, Bliddal H. Does the hip powder of Rosa canina (rose hip) reduce pain in osteoarthritis patients? – a meta-analysis of randomized controlled trials. Osteoarthr Cartil. 2008;16:965–972.

 PubMed Web of Science ®Google Scholar

Willich SN, Rossnagel K, Roll S, et al. Rose hip herbal remedy in patients with rheumatoid arthritis – a randomized controlled trial. Phytomedicine. 2010;17(2):87–93.

 Web of Science ®Google Scholar

Rein E, Kharazmi A, Winther K. A herbal remedy, hyben vital (stand powder of a subspecies of Rosa canina fruits), reduces pain and improves general wellbeing in patients with osteoarthritis – a double-blind, placebo-controlled, randomised trial. Phytomedicine. 2004;11(5):383–391.

 PubMed Web of Science ®Google Scholar

Warholm O, Skaar S, Hedman E, Mølmen HM, Eik L. The effects of a standardised herbal remedy made from a subtype of Rosa canina in patients with osteoarthritis: a double-blind, randomised, placebo-controlled clinical trial. Curr Ther Res. 2003;64:21–31.

 PubMed Web of Science ®Google Scholar

Kharazmi A, Winther K. Rose hip inhibits chemotaxis and chemiluminescence of human peripheral blood neutrophils in vitro and reduces certain inflammatory parameters in vivo. Inflammopharmacology. 1999; 7(4):377–386.

 Google Scholar

Winther K. Low-dose seed and shell powder from rose-hip (Rosa Canina) can alleviate symptoms of osteoarthritis and reduce C-reactive protein in patients suffering from osteoarthritis (abstract). Osteoarthritis Cartilage. 2014;22(Suppl):S321–S322.

 Google Scholar

Winther K, Hansen AS, Kharazmi A. A Dose-dependent impact of a standardised powder made from subspecies (Rosa canina) on WOMAC pain scores in patients with osteoarthritis of the hip and/or knee (abstract). Osteoarthritis Cartilage. 2009;17(1):S253. ISSN 1063 4584.

 Google Scholar

Winther K, Rossnagel K, Roll S, et al. A dose-dependent impact of a standardized powder made from subspecies of rose hip (Rosa canina) on HAQ pain score in patients with Rheumatoid arthritis (abstract). Ann Eur Cong Rheumatol EULAR, abstract no: 1554.

 Google Scholar

Winther K, Apel K, Thamsborg G. A powder made from seeds and shells of a rose hip subspecies (Rosa canina) reduces symptoms of knee and hip osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial. Scand J Rheumatol. 2005;34(4):302–308.

 PubMed Web of Science ®Google Scholar

Gürbüz I, Ustün O, Yesilada E, Sezik E, Kutsal O. Anti-ulcerogenic activity of some plants used as folk remedy in Turkey. J Ethnopharmacol. 2003;88(1):93–97.

 Web of Science ®Google Scholar

Christensen R, Tarp S, Altman RD, et al. Comparing different preparations and doses of rosehip powder in patients with osteoarthritis of the knee: an exploratory randomized active-controlled trial. Int J Clin Rheumatol. 2014;9(3):267–278. doi:10.2217/IJR.14.13.

 Google Scholar

Ginnerup-Nielsen E, Christensen R, Bliddal H, Zangger G, Hansen L, Henriksen M. Improved gait in persons with knee related mobility limitations by a rosehip food supplement: a randomized double-blind placebo-controlled trial. Gait Posture. 2015;42(3):340–347.

 Web of Science ®Google Scholar