Figures & data
Figure 1 Interaction of ligand with RET and cell-signaling pathways.
Abbreviations: AKT, serine/threonine protein kinase; ECLD, extracellular ligand domain; FRS 2, fibroblast growth factor receptor substrate 2; GDNF, glial cell line-derived neurotrophic factor; GFRα, GDNF family receptor; IRS 1–2, insulin receptor substrate 1 and 2; MAPK, mitogen-activated protein kinase; PI3K, phosphoinositide 3-kinase; RAS/ERK, extracellular signal-regulated kinase; PKC, protein kinase C; RET, rearranged during transcription; SHC, Src homology and collagen; TKD, tyrosine kinase domain; TMD, transmembrane domain.
Figure 2 VEGFR pathways within the tumor cell.
Abbreviations: AKT, serine/threonine protein kinase; FAK, focal adhesion kinase-1; MAPK, mitogen-activated protein kinase; NOS, nitric oxide synthase; PI3K, phosphoinositide 3-kinase; PLC, phospholipase; PKC, protein kinase; Shc, proteins containing Src homology-2 domains; RAS, rat sarcoma; VEGF, vascular endothelial growth factor; VEGFR, VEGF receptor.
Table 1 Major adverse events reported in 20% or more patients on vandetanib 300 mg/day versus placebo in MTC